PDE3B

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PDE3B

A gene on chromosome 11q15.1 that encodes a cyclic nucleotide phosphodiesterase, which plays a critical role in signal transduction, regulating intracellular cyclic nucleotide concentrations by hydrolysing second messengers cAMP and/or cGMP to AMP and GMP, and in turn regulating physiological processes. PDE3B may have a role in fat metabolism.
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Thompson, "Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function, " Pharmacology and Therapeutics, vol.
Essayan, "Cyclic nucleotide phosphodiesterases, " Journal
Vascular cyclic nucleotide phosphodiesterases (PDE1, PDE3, PDE4 and PDE5) were purified from smooth muscle of bovine aorta (Lugnier et al., 1986).
Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta.
Naylor, "Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes," Journal of Urology, vol.
Fidock, "Cloning and characterization of the human and mouse PDE7B, a novel cAMP-Specific cyclic nucleotide phosphodiesterase," Biochemical and Biophysical Research Communications, vol.
Advances in targeting cyclic nucleotide phosphodiesterases. Nat Rev Drug Discov 2014; 13:290-314.
Beavo, "Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling," Annual Review of Biochemistry, vol.
In the previous study, Insel's group had discovered that among a group of enzymes, cyclic nucleotide phosphodiesterases, one of the phosphodiesterases, PDE7B, was 10 times higher in CLL patients than in healthy individuals.
Cyclic nucleotide phosphodiesterases in health and disease.