cyclic nucleotide


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cy·clic nu·cle·o·tide

a nucleoside monophosphate in which the phosphoryl group is linked twice to the sugar moiety; for example, adenosine 3',5'-cyclic monophosphate (cAMP).
References in periodicals archive ?
Beavo, "Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases, " The Journal of Biological Chemistry, vol.
Endothelium-dependent and independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors.
Vandecasteele, "Compartmentation of Cyclic Nucleotide Signaling in the Heart The Role of Cyclic Nucleotide Phosphodiesterases," Circ.
Fidock, "Cloning and characterization of the human and mouse PDE7B, a novel cAMP-Specific cyclic nucleotide phosphodiesterase," Biochemical and Biophysical Research Communications, vol.
of Glasgow, UK) present the first major compendium on the science of cyclic nucleotide phosphodiesterases (PDEs) and their therapeutic and biomedical applications in some 15 years, a period during which new mammalian PDE families have been discovered and characterized and PDE-selective inhibitors have been successively marketed (including Viagra, Levitra, and Cialis).
The reduced platelet antiaggregatory activity exerted by both cyclic nucleotides (11) does not necessarily lead to impaired activation of cyclic nucleotide /specific kinase/ VASP pathways.
The stimulation of bovine epididymal sperm metabolism by cyclic nucleotide phosphodiesterase inhibitors.
Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
The award recognized the professors' contribution in the "demonstration that stimulation of the cyclic nucleotide signaling pathways can affect guidance molecules, the growth cone, and inhibition of axon regeneration in the injured spinal cord."
Objective: "This project aims to unite global efforts to target the highly druggable class of enzymes called cyclic nucleotide phosphodiesterases (PDEs) in the fight for neglected parasitic diseases (NPD).
Leavesley, "Perspectives on: Cyclic nucleotide microdomains and signaling specificity: Can we decipher the information content contained within cyclic nucleotide signals?" J.