cyclic nucleotide

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cy·clic nu·cle·o·tide

a nucleoside monophosphate in which the phosphoryl group is linked twice to the sugar moiety; for example, adenosine 3',5'-cyclic monophosphate (cAMP).


pertaining to or occurring in a cycle or cycles. The term is applied to chemical compounds that contain a ring of atoms in the nucleus.

cyclic adenosine monophosphate (AMP)
see cyclic adenosine monophosphate.
cyclic guanosine monophosphate (cGMP)
see cyclic guanosine monophosphate.
canine cyclic hematopoiesis
an abnormality of hematopoietic stem cells that results in detectable, cyclic fluctuations in numbers of circulating neutrophils. Affected dogs have an increased susceptibility to infections. The condition is inherited as an autosomal recessive in collies where it is occurs with a distinctive silver-gray coat color; called also gray collie syndrome.
cyclic neutropenia
see canine cyclic hematopoiesis (above).
cyclic non-breeder cows
cows demonstrating estrus regularly but not being submitted for mating; deferral of mating.
cyclic nucleotide
see cyclic nucleotide.
References in periodicals archive ?
Endothelium-dependent and independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors.
In this study we used the more lipophilic molecules 8-(4-Chlorophenylthio)-cAMP (8-pCPT-cAMP) and 8-(4-Chlorophenylthio)-cGMP (8-pCPT-cGMP), which are highly effective in PKA and PKG activation (28) and do not interfere with cyclic nucleotide phosphodiesterases (28); because these analogs have not been previously used in studies of platelets from obese individuals, we also evaluated whether their antiaggregatory effect is decreased in central obesity.
Cyclic nucleotide metabolism in mouse epididymal spermatozoa during capacitation in vitro.
Traditional image analysis approaches require investigators to select regions of interest (ROIs) to interpret cyclic nucleotide signals in cells.
Thus, two opposing cyclic nucleotide pathways may simultaneously regulate the activity of the respective molecular motors responsible for aggregation and dispersion in a tug-of-war manner--increased cGMP and [Ca.
Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes.
cGMP is an important second messenger which mediates the response of the cell to extracellular stimulus through the activation of protein kinase G (PKG), cGMP-phosphodiesterases (PDEs) and cyclic nucleotide gated ion channels (CNG).
Cyclic nucleotide PDEs consist of 11 gene families, each having one or more different members or "isoforms.
IBMX, theophylline, and papaverine are not selective for any of the cyclic nucleotide phosphodiesterase isozymes (Thompson, 1993); they inhibit phosphodiesterases that hydrolyze cGMP as well as those that hydrolyze cAMP.
Pharmaceutical developers have been studying these enzymes as potential drug targets to modulated cyclic nucleotide levels in diseases where their levels are important, such as asthma and heart disease.
1 One of these agents, papaverine, is a potent vasoplegic substance that blocks the breakdown of cyclic nucleotides and can also cause vasodilatation by inhibiting phosphodiesterase.
Cyclic nucleotides and atherosclerosis: studies in primary culture of human aortic cells.