cyclic nucleotide

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cy·clic nu·cle·o·tide

a nucleoside monophosphate in which the phosphoryl group is linked twice to the sugar moiety; for example, adenosine 3',5'-cyclic monophosphate (cAMP).


pertaining to or occurring in a cycle or cycles. The term is applied to chemical compounds that contain a ring of atoms in the nucleus.

cyclic adenosine monophosphate (AMP)
see cyclic adenosine monophosphate.
cyclic guanosine monophosphate (cGMP)
see cyclic guanosine monophosphate.
canine cyclic hematopoiesis
an abnormality of hematopoietic stem cells that results in detectable, cyclic fluctuations in numbers of circulating neutrophils. Affected dogs have an increased susceptibility to infections. The condition is inherited as an autosomal recessive in collies where it is occurs with a distinctive silver-gray coat color; called also gray collie syndrome.
cyclic neutropenia
see canine cyclic hematopoiesis (above).
cyclic non-breeder cows
cows demonstrating estrus regularly but not being submitted for mating; deferral of mating.
cyclic nucleotide
see cyclic nucleotide.
References in periodicals archive ?
Vandecasteele, "Compartmentation of Cyclic Nucleotide Signaling in the Heart The Role of Cyclic Nucleotide Phosphodiesterases," Circ.
The reduced platelet antiaggregatory activity exerted by both cyclic nucleotides (11) does not necessarily lead to impaired activation of cyclic nucleotide /specific kinase/ VASP pathways.
La Jolla, CA) has patented isolated nucleic acid sequences that encode human olfactory cyclic nucleotide gated (CNG) channel subunits, and the corresponding polypeptides.
Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
Objective: "This project aims to unite global efforts to target the highly druggable class of enzymes called cyclic nucleotide phosphodiesterases (PDEs) in the fight for neglected parasitic diseases (NPD).
Leavesley, "Perspectives on: Cyclic nucleotide microdomains and signaling specificity: Can we decipher the information content contained within cyclic nucleotide signals?
Eleven classes of PDE enzymes with distinct tissue distributions, cyclic nucleotide selectivity, and regulatory factors are known.
Where PDE5 breaks down cyclic nucleotides in response to the vital signaling molecule nitric oxide (NO), PDE1 affects cyclic nucleotide pathways sensitive to Calcium (Ca2+), another major player in cardiac disease, according to the authors.
Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes.