cyclic neutropenia


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neutropenia

 [noo″tro-pe´ne-ah]
diminished numbers of neutrophils in the blood.
congenital neutropenia infantile genetic agranulocytosis.
cyclic neutropenia a chronic form marked by regular, periodic episodic recurrences, associated with malaise, fever, stomatitis, and various infections. Called also periodic neutropenia.
drug-induced neutropenia that caused by medications; the most common mechanisms are immunological (formation of antibodies destructive to neutrophils or of immune complexes that bind to neutrophils), followed by inhibition of granulopoiesis and direct damage to bone marrow or precursor cells of the granulocytic series.
idiopathic neutropenia agranulocytosis.
Kostmann's neutropenia infantile genetic agranulocytosis.
malignant neutropenia agranulocytosis.
neonatal neutropenia, alloimmune neutropenia in the newborn due to in utero incompatibility between its immunoglobulin G antigens and those of the mother's blood; the mother's blood produces antibodies that cross the placenta and sensitize fetal neutrophils. Affected infants may have fever, pneumonia, septicemia, and other infections that can be fatal. The condition eventually resolves as the infant's immunoglobulin replaces that from the mother.
periodic neutropenia cyclic neutropenia.

per·i·od·ic neu·tro·pe·ni·a

neutropenia recurring at regular intervals (14-45 days), in association with various types of infectious diseases, for example, stomatitis, cutaneous ulcers, furuncles, arthritis, and others.
Synonym(s): cyclic neutropenia

cyclic neutropenia

A disorder characterized by episodic severe neutropenia occurring in 3-4 wk cycles, accompanied by maturational arrest of myeloid precursors in BM Clinical Fever, oral ulceration, cervical lymphadenopathy, multiple acute local infections which are rarely fatal Management If symptomatic, antibiotics–eg, aminoglycosides, penicillin

per·i·od·ic neu·tro·pe·ni·a

(pēr'ē-od'ik nū'trō-pē'nē-ă)
Neutropenia recurring at regular intervals (14-45 days), in association with various infectious diseases (e.g., stomatitis).
Synonym(s): cyclic neutropenia.
References in periodicals archive ?
Jones, "Cyclic neutropenia: review of clinical manifestations and management," American Journal of Pediatric Hematology Oncology, vol.
Ballmaier, "The spectrum of ELANE mutations and their implications in severe congenital and cyclic neutropenia," Human Mutation, vol.
To our knowledge, this is the first case of pulmonary TB described in association with cyclic neutropenia and chronic diarrhoea in the African continent.
Cyclic neutropenia. Semin Hematol 2002;39(2):89-94.
Differential diagnosis of neutropenia (adapted) [1] Neutropenia caused by intrinsic defects in granulocytes or their progenitors Cyclic neutropenia Severe congenital neutropenia Shwachman-Diamond syndrome Reticular dysgenesis (associated with severe combined immunodeficiency) Albinism/neutropenia syndromes (including Chediak-Higashi) Familial benign neutropenia Bone marrow failure syndromes (congenital and acquired) Neutropenia caused by extrinsic factors Infection Drug-induced neutropenia (e.g.
In cyclic neutropenia, G-CSF shortens the periods of neutropenia as well as the length of the neutropenic cycle.
New therapeutic interventions like cord blood transplantation for these patients is being investigated but the results depend upon the compatibility of the donor.9 Cyclic neutropenia is not associated with risk of malignancy or conversion to leukaemia.3 but recent studies show that some ELANE mutations may possibly be associated with severe congenital neutropenia and increased risk of acute mycboid leukaemia.10
Cyclic neutropenia is a rare blood disorder that may occur spontaneously or it may be autosomal dominant.