cyclic guanosine monophosphate


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to cyclic guanosine monophosphate: Cyclic adenosine monophosphate

guanosine

 [gwah´no-sēn]
a nucleoside, guanine riboside, one of the major constituents of RNA.
cyclic guanosine monophosphate a cyclic nucleotide, guanosine 3′,5′-cyclic monophosphate, an intracellular “second messenger” similar in action to cyclic adenosine monophosphate; the two cyclic nucleotides activate different protein kinases and usually produce opposite effects on cell function. Abbreviated 3′,5′-GMP, cGMP, and cyclic GMP.
guanosine monophosphate (GMP) a nucleotide important in metabolism and RNA synthesis.
guanosine triphosphate (GTP) a nucleotide required for RNA synthesis and involved in energy metabolism.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
There are other ways smooth muscle cells in the penis can relax, resulting in an erection: During sexual arousal penile nerves release nitric oxide (NO), which activates the smooth muscle cells to release the messenger cyclic guanosine monophosphate (cGMP) inside the cells.
Sexual Health For Men: The Complete Guide
Nitric oxide release triggers the production of cyclic guanosine monophosphate, which leads to decreased intracellular calcium, smooth muscle relaxation, and penile erection.
Restoring sexual function: which medications show benefit?; When trying centrally acting or topical agents, also address patients' psychopathologies
Phosphodiesterase-5 degrades cyclic guanosine monophosphate, a compound that causes vascular smooth-muscle relaxation.
New drugs scale high-altitude pulmonary edema: novel therapies for prevention and treatment include inhaled [beta]-agonists, sildenafil, and dexamethasone
It then diffuses to the vascular smooth-muscle cells and stimulates guanylate cyclase to catalyze the production of cyclic guanosine monophosphate (cGMP)--a potent vascular smooth-muscle relaxing agent--resulting in vasodilation and increased blood flow.
Beneficial effects of insulin on endothelial function, inflammation, and atherogenesis and their implications
Other authors propose that the defect in malakoplakia may be due to low levels of cyclic guanosine monophosphate in mononuclear cells, resulting in deficient lysosomal bacterial degradation and the inability of cells to release the lysosomal enzymes.
Malakoplakia of liver diagnosed by a needle core biopsy; a case report and review of the literature. (Case Reports)
Nitric oxide is a biogenic messenger, an EDRF (15,16), and it activates the guanylyl cyclase system (17) [it converts guanosine triphosphate to cyclic guanosine monophosphate (cGMP)], raising the cGMP pool and therefore inducing, among other things, vasodilatation (17) by lowering the intracellular calcium ion (16).
Recurrent Acute Respiratory Tract Infections in Areas With High Nitrate Concentrations in Drinking Water

Medical browser ?
Full browser ?