cyclic guanosine monophosphate

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Related to cyclic guanosine monophosphate: Cyclic adenosine monophosphate


a nucleoside, guanine riboside, one of the major constituents of RNA.
cyclic guanosine monophosphate a cyclic nucleotide, guanosine 3′,5′-cyclic monophosphate, an intracellular “second messenger” similar in action to cyclic adenosine monophosphate; the two cyclic nucleotides activate different protein kinases and usually produce opposite effects on cell function. Abbreviated 3′,5′-GMP, cGMP, and cyclic GMP.
guanosine monophosphate (GMP) a nucleotide important in metabolism and RNA synthesis.
guanosine triphosphate (GTP) a nucleotide required for RNA synthesis and involved in energy metabolism.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
References in periodicals archive ?
There are other ways smooth muscle cells in the penis can relax, resulting in an erection: During sexual arousal penile nerves release nitric oxide (NO), which activates the smooth muscle cells to release the messenger cyclic guanosine monophosphate (cGMP) inside the cells.
Nitric oxide release triggers the production of cyclic guanosine monophosphate, which leads to decreased intracellular calcium, smooth muscle relaxation, and penile erection.
Phosphodiesterase-5 degrades cyclic guanosine monophosphate, a compound that causes vascular smooth-muscle relaxation.
It then diffuses to the vascular smooth-muscle cells and stimulates guanylate cyclase to catalyze the production of cyclic guanosine monophosphate (cGMP)--a potent vascular smooth-muscle relaxing agent--resulting in vasodilation and increased blood flow.
Other authors propose that the defect in malakoplakia may be due to low levels of cyclic guanosine monophosphate in mononuclear cells, resulting in deficient lysosomal bacterial degradation and the inability of cells to release the lysosomal enzymes.
Nitric oxide is a biogenic messenger, an EDRF (15,16), and it activates the guanylyl cyclase system (17) [it converts guanosine triphosphate to cyclic guanosine monophosphate (cGMP)], raising the cGMP pool and therefore inducing, among other things, vasodilatation (17) by lowering the intracellular calcium ion (16).

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