cyclic guanosine monophosphate

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Related to cyclic guanosine monophosphate: Cyclic adenosine monophosphate

guanosine

[gwah´no-sēn]

a nucleoside, guanine riboside, one of the major constituents of RNA.

cyclic guanosine monophosphate a cyclic nucleotide, guanosine 3′,5′-cyclic monophosphate, an intracellular “second messenger” similar in action to cyclic adenosine monophosphate; the two cyclic nucleotides activate different protein kinases and usually produce opposite effects on cell function. Abbreviated 3′,5′-GMP, cGMP, and cyclic GMP.

guanosine monophosphate (GMP) a nucleotide important in metabolism and RNA synthesis.

guanosine triphosphate (GTP) a nucleotide required for RNA synthesis and involved in energy metabolism.

cyclic guanosine monophosphate (cGMP)

a substance that mediates the action of certain hormones in a manner similar to that of cyclic adenosine monophosphate. In response to the stimulation of cholinergic receptors in a parasympathetic nerve, guanylate cyclase triggers the conversion of guanosine triphosphate to cGMP with the release of various enzymes. Atropine, an anticholinergic drug, can block cholinergic stimulation by means of this process.

References in periodicals archive ?

Sildenafil, in the form of a citrate salt, is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase Type 5 (PDE5).

NovaDel Reports Opening of Duromist[TM] original IND with FDA

In preclinical models, this activation of GC-C leads to increases in cyclic guanosine monophosphate (cGMP), anion secretion, fluid secretion, and intestinal transit.

Ironwood Pharmaceuticals Provides First Quarter 2010 Investor Update

Activation of GC-C leads to increases in intracellular and extracellular cyclic guanosine monophosphate (cGMP).

Ironwood and Forest to Present Linaclotide Phase 3 Chronic Constipation Data

PDE5 inhibitors such as sildenafil citrate (Viagra([R])), vardenafil (Levitra([R])) and tadalafil (Cialis([R])), which inhibit the breakdown of cyclic guanosine monophosphate, have been shown to be effective treatments for ED.

VIVUS Initiates Second Pivotal Phase 3 Trial of Avanafil for Treatment of Erectile Dysfunction