cyclic GMP


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GMP

 
3′,5′-GMP (cyclic GMP) cyclic guanosine monophosphate.

guanosine

 [gwah´no-sēn]
a nucleoside, guanine riboside, one of the major constituents of RNA.
cyclic guanosine monophosphate a cyclic nucleotide, guanosine 3′,5′-cyclic monophosphate, an intracellular “second messenger” similar in action to cyclic adenosine monophosphate; the two cyclic nucleotides activate different protein kinases and usually produce opposite effects on cell function. Abbreviated 3′,5′-GMP, cGMP, and cyclic GMP.
guanosine monophosphate (GMP) a nucleotide important in metabolism and RNA synthesis.
guanosine triphosphate (GTP) a nucleotide required for RNA synthesis and involved in energy metabolism.

cyclic GMP

n. Abbr. cGMP
A cyclic nucleotide of guanosine that is produced inside cells in response to external stimuli, such as hormones, and triggers various biochemical pathways within the cell.

cyclic GMP (guanosine monophosphate)

a nucleotide that usually produces cell responses opposite to those of CYCLIC AMP. Analogous with cAMP, it is present in much lower concentrations.
References in periodicals archive ?
The cyclic nucleotide PDEs, which hydrolyze cyclic AMP and cyclic GMP, play a pivotal role in intracellular signaling cascades (Lugnier, 2006).
In addition, previous studies have shown that increases in the cyclic GMP level cause inhibition of PDE3, thereby, increasing the cyclic AMP level (Eckly and Lugnier, 1994; Lugnier and Komas, 1993).
Modulation of vascular cyclic nucleotide phosphodiesterases by cyclic GMP: role in vasodilatation.
Abbreviations: ANP, atrial natriuretic peptide; BFBO, butanol fraction of Berberis orthobotrys; Cyclic GMP cyclic guanosine 3',5'-monophosphate; Cyclic AMP, cyclic adenosine 3',5'-monophosphate; eNOS, endothelial nitric oxide synthase; PDE, phosphodiesterase; oxLDL, oxidized low density lipoprotein; EGTA, ethylene glycolbis(2-aminoethylether)-N,N,N,,N,-tetraacetic acid; SNP, sodium nitroprusside; 1EB10, l-ethyl-2-benzimidazolinone; L-NA, N-co-nitro-L-arginine; EFBO, ethyl acetate fraction of Berberis orthobotrys; ARBO, aqueous residue of Berberis orthobotrys; 1-Kc, intermediate-conductance calcium-activated potassium channels.
Then the researchers used isolated fat cells and treated the cells directly with cyclic GMP and identified a "browning" effect as well.
1990, Purification and chemical characterization of peptide GI, an invertebrate neuropeptide that stimulates cyclic GMP metabolism.
Beyond nitric oxide and cyclic GMP. Circulation 1995;92: 3337-49.
A small molecule called cyclic GMP has now been recognized by scientists as the crucial messenger chemical in both types of cells that sense light in animals' eyes.
The recent direct evidence that the internal messenger is cyclic GMP rather than calcium ions comes out of experiments with a powerful, relatively new technique called "patch clamping" (SN: 11/7/81, p.
5 NATURE, however, two research groups--those of Yau and of Cobbs and Pugh -- report that cones of catfish and of larval tiger salamander do use cyclic GMP as a messenger.
Along with his mentor, he demonstrated that nitric oxide and cyclic GMP inhibit smooth muscle and mesangial cell growth and proliferation induced by serum and various growth factors, such as platelet-derived growth factor, epidermal growth factor, insulin-like growth factor, and fibroblast growth factor.

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