cyclase

Also found in: Dictionary, Encyclopedia, Wikipedia.

Related to cyclase: Guanylate cyclase

cyclase

[si´klās]

an enzyme that catalyzes the formation of a cyclic phosphodiester.

cy·clase

(sī'klās),

Descriptive name applied to an enzyme that forms a cyclic compound, for example, adenylate cyclase.

cyclase

/cy·clase/ (si´klās) an enzyme that catalyzes the formation of a cyclic phosphodiester.

cy·clase

(sī'klās)

Descriptive name applied to an enzyme that forms a cyclic compound; e.g., adenylate cyclase.

cyclase

an enzyme that catalyzes the formation of a cyclic phosphodiester.

References in periodicals archive ?

CHAT and TH expression are controlled through separate transcriptional promoter pathways, comprising cAMP-dependent processes (adenylyl cyclase, protein kinase A, CREB, AP-1) as well as trophic factors such as brain derived neurotrophic factor, ciliary neurotrophic factor, repressor element-1 silencing transcription factor/neuron restrictive silencer factor, and bone morphogenetic protein-9 (Lewis-Tuffin et al.

Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells

i]-adenylyl cyclase signaling complex in brain tissue of two closely related scorpaenid fish species.

Hydrostatic Pressure Alters the Time Course of GTP[S] Binding to G Proteins in Brain Membranes from Two Congeneric Marine Fishes

Adenylyl cyclase and cAMP also participate in important metabolic, cardiovascular, and hormonal functions in the periphery, and we recently found that neonatal chlorpyrifos exposure leads to disruption of cardiac and hepatic cell signaling in adulthood (Meyer et al.

Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood

Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

Low doses of bisphenol A and diethylstilbestrol impair [Ca.sup.2+] signals in pancreatic [alpha]-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans

The product is a soluble guanylate cyclase stimulator that has been approved since 2013 for the treatment of adults suffering from this life-threatening disorder of the lungs.

Bayer commences trial to evaluate riociguat in children

Riociguat was discovered by Bayer and is the first member of a novel class of compounds, the stimulators of soluble guanylate cyclase (sGC).

Germany : U. S. FDA Grants Priority Review to Bayer s Riociguat for the Treatment of two Life-Threatening Pulmonary Hypertension Indications

The medicinal activities of forskolin are due to its ability to activate the enzyme adenylyl cyclase and therefore to increase the levels of cyclic AMP (cAMP) in the cells.

Denmark - Elucidation of forskolin biosynthetic pathway in Coleus forskohlii

In the present study we evaluated the effects in adulthood of CPF exposure of rats during different developmental windows, using the adenylyl cyclase (AC) signaling cascade, which mediates the cellular responses to numerous neurotransmitters.

Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure

Linaclotide is an investigational guanylate cyclase type-C agonist (GCCA) for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic constipation.

Ironwood and Forest to Present 17 Linaclotide-Related Abstracts at Digestive Disease Week[R] 2012

Riociguat was discovered by Bayer and represents the first member of a novel class of compounds, the stimulators of soluble guanylate cyclase (sGC).

Germany : Bayer s Riociguat for Patients with Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Arterial Hypertension Submitted For Regulatory Approval in the U.S. and EU

Although CPF exposure on GD17-20, PN1-4, or PN11-14 altered the ability of 5HT to modulate adenylyl cyclase, this change did not correspond with the effects on 5HT receptors, suggesting an additional set of effects on proteins that transduce the 5HT signal.

Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling

In conjunction, Merck said it has signed a worldwide collaboration to develop and commercialise soluble guanylate cyclase (sGC) modulators with Bayer AG.