CHAT and TH expression are controlled through separate transcriptional promoter pathways, comprising cAMP-dependent processes (adenylyl cyclase
, protein kinase A, CREB, AP-1) as well as trophic factors such as brain derived neurotrophic factor, ciliary neurotrophic factor, repressor element-1 silencing transcription factor/neuron restrictive silencer factor, and bone morphogenetic protein-9 (Lewis-Tuffin et al.
signaling complex in brain tissue of two closely related scorpaenid fish species.
and cAMP also participate in important metabolic, cardiovascular, and hormonal functions in the periphery, and we recently found that neonatal chlorpyrifos exposure leads to disruption of cardiac and hepatic cell signaling in adulthood (Meyer et al.
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase
The product is a soluble guanylate cyclase
stimulator that has been approved since 2013 for the treatment of adults suffering from this life-threatening disorder of the lungs.
Riociguat was discovered by Bayer and is the first member of a novel class of compounds, the stimulators of soluble guanylate cyclase
The medicinal activities of forskolin are due to its ability to activate the enzyme adenylyl cyclase
and therefore to increase the levels of cyclic AMP (cAMP) in the cells.
In the present study we evaluated the effects in adulthood of CPF exposure of rats during different developmental windows, using the adenylyl cyclase
(AC) signaling cascade, which mediates the cellular responses to numerous neurotransmitters.
Linaclotide is an investigational guanylate cyclase
type-C agonist (GCCA) for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic constipation.
Riociguat was discovered by Bayer and represents the first member of a novel class of compounds, the stimulators of soluble guanylate cyclase
Although CPF exposure on GD17-20, PN1-4, or PN11-14 altered the ability of 5HT to modulate adenylyl cyclase
, this change did not correspond with the effects on 5HT receptors, suggesting an additional set of effects on proteins that transduce the 5HT signal.
In conjunction, Merck said it has signed a worldwide collaboration to develop and commercialise soluble guanylate cyclase
(sGC) modulators with Bayer AG.