cyclamates


Also found in: Dictionary, Encyclopedia.
Related to cyclamates: aspartame, saccharin

cyclamates

A family (calcium cyclamate and its metabolites, cyclohexylamine, cyclamic acid and sodium cyclamate) of artificial sweeteners, banned by the FDA in 1970 when they were linked to bladder cancer in rats given extremely high doses. Subsequent studies have failed to reveal direct, intrinsic genotoxicity of cyclamate, although when added to saccharin (another artificial sweetener), there was an additive tumourigenic effect, causing a focal increase in tumours of the bladder epithelium.
References in periodicals archive ?
SUMMARY: To evaluate the effects of sodium cyclamate on the rat placenta by its administration in the period of embryogenesis.
Spokesman Dr Tim Lobstein said: "Their sperm count might be reduced because tests have shown that excessive levels of cyclamates could reduce testosterone levels and shrivel the size of the testicles.
For the former, the development of sweeteners that could be produced from less expensive means - for example, sugar beets, corn syrup and cyclamates - led to a mad scramble for acts of Congress, including price supports and quotas.
These are the people who terrorized the public with death at the wheel of the Corvair, death at the bite of an apple or cranberry, death at the swallow of cyclamates.
Food and Drug Administration, the committee spent more than a year reviewing all existing studies on cyclamates and cancer.
a cut in the maximum recommended intake for cyclamates and a ban or reduction in its use in certain categories of food (water-based beverages and confectionary).
Non-nutritive sweeteners of major commercial significance - saccharin, cyclamates and aspartame - all have higher sweetness levels than sugar, says Hellekant, but they are unstable, either in processing or upon storage.
1969 - Cyclamates, used to sweeten soft drinks, are labeled cancer-causers and taken off the market.
Think back to the banning of cyclamates and their replacement by saccharin.
Indeed, scientists are questioning regulations governing such chemicals as dioxin, DDT, saccharin and cyclamates, which have produced cancers in some lab animal test but may not be as harmful to humans.
It appears in the composition of the products as sodium and calcium cyclamates and cyclamic acid.