From the 10th to 14th days of pregnancy, five rats received a daily intraperitoneal injection of sodium cyclamate
at a dosage of 60 mg/kg of body weight (Labsynth Ltd., Diadema, SE Brazil) for five days.
Group E served as experimental group and was given sodium cyclamate
60mg/kg/day through oral gavage tube for two months.
As early as 1962, internal Sugar Association memos had acknowledged the potential links between sugar and chronic diseases, but at the time sugar executives had a more pressing problem: Weight-conscious Americans were switching in droves to diet sodas--particularly Diet Rite and Tab--sweetened with cyclamate
Artificial sweeteners such as saccharin, cyclamate
, aspartame and sucralose rapidly emerged as low-calorie, tooth-friendly sugar alternatives.
Particularly compelling are the chapters on artificial sweeteners, which blend descriptions of aggressive advertising campaigns with details of backlash against products like saccharin and cyclamate
Sweeteners with alitame, cyclamate
, and steviol glycosides are not approved as food ingredients in the United States but can be found in countries by sheer negligence.
Additives are harmful for human health, especially monosodium glutamate, aspartame, saccharin, sodium cyclamate
, sulfites, nitrates, nitrites and antibiotics.
Mentes  demonstrated the cariogenic effect of paediatric medicines, observing variations of pH in plaque produced after rinsing with two versions of the same medicine: one containing only sucrose and another containing saccharine, cyclamate
and sorbitol, during a one hour period.
Through the use of a new analytical method, the researchers were able to look for seven different artificial sweeteners (cyclamate
, acesulfame, saccharin, aspartame, neotame, neohesperidin dihydrochalcone and sucralose) simultaneously, and show, for the first time, that a number of commonly used artificial sweeteners are present in German waste and surface water.
"Middle-age and older people still remember the controversy over cyclamate
being carcinogenic and its ban," the category manager adds.
According to the National Cancer Institute, www.cancer.gov, "Questions about artificial sweeteners and cancer arose when early studies showed that cyclamate
in combination with saccharin caused bladder cancer in laboratory animals.