MtCIDAS was measured in permeabilized compound and rotenone-treated (22 h + 2 h) cybrid
cells containing LHON mutation (11,778) using a bioluminescence method.
This entirely mutation-dependent reduction in energy supply is supported by studies using cybrids
carrying LHON mutations as well as peripheral lymphocytes from patients and mutation carriers .
We cultured transmitochondrial cybrids
in high-glucose (4.
Production and characterization of intergeneric diploid cybrids
derived from symmetric fusion between Microcitrus papuana Swingle and sour orange (Citrus aurantium).
However, a TBTC concentration [greater than or equal to] 60 nM was required to affect the MIMP of the Awt cybrid
A decline in complex I-sustained cell respiration and ATP production has been reported in assays performed on isolated mitochondria derived from muscle, Epstein-Barr Virus- (EBV-) transformed leukocytes, peripheral blood mononuclear cells (PBMCs), and cybrids
TECHNIQUE AND ITS CONTRIBUTION TO NEURODEGENERATION RESEARCH
To address cyber threats in CSDP, Estonia is organising in cooperation with the European Defence Agency a strategic table-top cyber-exercise EU CYBRID
2017 for EU Ministers of Defence during their informal meeting in Tallinn on 7 September 2017.
We have been using cybrid
studies to evaluate inheritance patterns in RC disorders (10), which requires isolation and evaluation of many clones (>20).
The clonal cybrid
cells between the cells lacking mitochondrial DNA and fibroblasts from a patient with the A3243G mutation showed poor respiration, an increased ratio of lactate to pyruvate, and marked defects in the mitochondrial morphology and respiratory chain complex I and IV activities (19).
The origin of the complex I defect in PD has been investigated through cybrid