The rate of PD-L1 expression reported in the literature varies depending on the cut-off level
used or localization of staining (cytoplasmic and/or membranous).
We performed a receiver operating characteristics (ROC) curve analysis to determine the most suitable cut-off levels
of serum HO-1 and other blood biomarkers for detecting an AE and predicting hospital death among patients having an AE.
Several studies compared ROMA with CA125 and HE4 with contradicting results, which can be attributed to the subgroups analyzed, populations studied, oncology profile of the investigating center, cut-off levels
of diagnostic tests, and choice of certain ovarian pathologies [23-26].
Patients' records were comprehensively reviewed in order to build a database containing age at diagnosis and age at evaluation; JIA subtype according to International League of Associations for Rheumatology (ILAR) classification ; reason of admission (fresh diagnosis of JIA, disease flare, continuation of biological treatment, and checkup visit); active joint count; JADAS27 value and disease activity level determined using cut-off levels
proposed by Consolaro et al.
Our aim in this study was to evaluate if f-calprotectin below a predefined cut-off level
after treatment for active UC was a reliable biomarker of endoscopic mucosal healing.
Using the most accurate cut-off level
of 1.32 mg/L or higher, the sensitivity was 67% and the specificity was 97%.
The researchers also established a specific cut-off level
at which the concentration of 1,5-AG became a reliable predictor of which women had diabetes.
[sup],,,, This is in spite of the fact that the cut-off level
for anemia in our study was higher as compared to other studies where the cut-off level
was 10 g/dl.
RMI developed by Jacobs et al5 for distinguishing benign and malignant pelvic masses pre-operatively at a cut-off level
of 200 had a sensitivity of 85.4% and a specificity of 96.9%.
The IgG4 and IgM antibody levels to Sd30 were found to be above the cut-off level
in 38 out of 40 [CFA.sup.+] arthritis patients (Fig.
Table 2 shows the distribution of pancreatic enzyme elevations above and below the cut-off level
. Above three times the ULN, specificity for AP was similar, with lipase and amylase being 92% and 93% specific for AP, respectively.
This cut-off level
can be useful to predict the probability of embryo transfer, without predictive value for clinical pregnancy.