The rate of PD-L1 expression reported in the literature varies depending on the
cut-off level used or localization of staining (cytoplasmic and/or membranous).
We performed a receiver operating characteristics (ROC) curve analysis to determine the most suitable
cut-off levels of serum HO-1 and other blood biomarkers for detecting an AE and predicting hospital death among patients having an AE.
Several studies compared ROMA with CA125 and HE4 with contradicting results, which can be attributed to the subgroups analyzed, populations studied, oncology profile of the investigating center,
cut-off levels of diagnostic tests, and choice of certain ovarian pathologies [23-26].
Patients' records were comprehensively reviewed in order to build a database containing age at diagnosis and age at evaluation; JIA subtype according to International League of Associations for Rheumatology (ILAR) classification [2]; reason of admission (fresh diagnosis of JIA, disease flare, continuation of biological treatment, and checkup visit); active joint count; JADAS27 value and disease activity level determined using
cut-off levels proposed by Consolaro et al.
Our aim in this study was to evaluate if f-calprotectin below a predefined
cut-off level after treatment for active UC was a reliable biomarker of endoscopic mucosal healing.
Using the most accurate
cut-off level of 1.32 mg/L or higher, the sensitivity was 67% and the specificity was 97%.
The researchers also established a specific
cut-off level at which the concentration of 1,5-AG became a reliable predictor of which women had diabetes.
[sup][6],[7],[8],[9],[10] This is in spite of the fact that the
cut-off level for anemia in our study was higher as compared to other studies where the
cut-off level was 10 g/dl.
RMI developed by Jacobs et al5 for distinguishing benign and malignant pelvic masses pre-operatively at a
cut-off level of 200 had a sensitivity of 85.4% and a specificity of 96.9%.
The IgG4 and IgM antibody levels to Sd30 were found to be above the
cut-off level in 38 out of 40 [CFA.sup.+] arthritis patients (Fig.
Table 2 shows the distribution of pancreatic enzyme elevations above and below the
cut-off level. Above three times the ULN, specificity for AP was similar, with lipase and amylase being 92% and 93% specific for AP, respectively.
This
cut-off level can be useful to predict the probability of embryo transfer, without predictive value for clinical pregnancy.