2014) that demonstrated the positive effects of curcuminoids
for a significant reduction in pulse wave velocity (a measure of arterial stiffness) along with a significant decrease in markers of inflammation (increase in serum adiponectin and decrease in leptin).
This study suggested that curcuminoids
have no statistically significant differences in efficacy outcomes compared to NSAIDs.
Methods: The effects of CuraMed[R] 500-mg capsules (333 mg curcuminoids
) and Curamin[R] 500-mg capsules (350 mg curcuminoids
and 150 mg boswellic acid) taken orally three times a day for 12 weeks in 201 patients was investigated in a three-arm, parallel-group, randomized, double-blinded, placebo-controlled trial.
A curcumin 500 mg capsule, containing 333 mg curcuminoids
was given three times daily for 12 weeks to one group.
Five studies compared curcuminoid
formulations against placebo, four studies compared boswellia formulation against placebo, two trials compared Curcuma domestica against ibuprofen, one study compared boswellia against valdecoxib; however, this was not included in the analysis due to the NSAID being withdrawn from some markets.
Compared to the placebo control group, 45 DRCS patients who received combined curcuminoids
(1,500 mg/day) and piperine (15 mg/day) for a period of 4 weeks had higher glutathione and lower malonedialdehyde concentration at the end of the trial.
In this study, we investigated whether the effects of the naturally occurring curcuminoids
curcumin and bisdemethoxy curcumin (GG6), together with a pyrazole analogue obtained by GG6 cyclization, on macrophage immunophenotype and function as reported in a variety of cell types could be reproduced in human monocyte-derived macrophages.
Normolle et al., "Dose escalation of a curcuminoid
formulation," BMC Complementary and Alternative Medicine, vol.
Of these hydrogenated curcuminoid
compounds, only tetrahydrodemethoxycurcumin is a constituent of CuroWhite.
Croci et al., "Synthesis and characterization of 68Ga-labeled curcumin and curcuminoid
complexes as potential radiotracers for imaging of cancer and alzheimers disease," Inorganic Chemistry, vol.
biosynthesis by two type III polyketide synthases in the herb Curcuma longa," Journal of Biological Chemistry, vol.
Jia et al., "An integrated strategy for establishment of curcuminoid
profile in turmeric using two LC-MS/MS platforms," Journal of Pharmaceutical and Biomedical Analysis, vol.