(5) In our study, despite being with lower coefficiency values, we found negative and significant correlations between the thicknesses of retinal layer measured at 1 mm distant to fovea centralis and drug consumption duration, cumulative dose
of drug, dose of drug per kilogram of actual and lean body masses.
In the current 116-patient study, the average cumulative dose
was 309.8 mg/kg in the high-dose group and 170.8 mg/kg in the low-dose group (P less than .000).
The possible associations with RNMB identified in our audit are also consistent with previous studies, which have shown that RNMB is associated with a higher cumulative dose
of neuromuscular blocking drug (13), a shorter interval between final dose and arrival in the PACU (13,14) and a shorter duration of anaesthesia (14).
However, deaths have been reported with cumulative doses
as low as 5.5 mg (2).
Using even the latter dose (1.5 mg weekly), achieving the mean cumulative dose
of 4015 mg associated with moderate to severe (grade 3-4) valve abnormalities cited in the NEJM study would take a prostate cancer patient more than 51 years!
"These patients were relatively young, their cumulative dose
was relatively low, and yet they still appeared to benefit from" leuprolide treatment, Dr.
In a multivariate regression analysis involving 162 SLE patients with osteonecrosis and an equal number of matched controls who had SLE but not osteonecrosis, the only independent predictor of osteonecrosis was a high cumulative dose
of corticosteroids; in the osteonecrosis group, it averaged 31 g.
So one can argue that relapse can occur as cumulative dose
of 120mg/kg was not achieved.
Consider the estimated response to cumulative dose
, adjusted for sex and birth year (Table 4): For all childhood cancers we estimated an increase in risk per mSv cumulative dose
of 2.8% (95% confidence interval [CI]: 0.8%, 4.8%) for the entire cohort and 4.0% (95% CI: 1.7%, 6.4%) for children with stable residence.
Patients and Methods: Patients who were started on doxorubicin-based chemotherapy during the study period and had completed at least 300 mg/m2 cumulative dose
were included in this study.
The primary analysis indicated no association between the use of pioglitazone and the risk of bladder cancer and no association was found between the risk of bladder cancer and the duration of pioglitazone use, increased cumulative dose
of pioglitazone or the time since initiating pioglitazone.
The median dose of betamethasone decreased from 28 mg at baseline to 0 mg at the following visits, and the cumulative dose
after 2 years was 77 mg, which corresponds to less than 1 mg prednisolone daily.