A 2016 study in Oregon (7), which did not include tramadol (a predictor of long-term use according to current data), reported similar findings: opioid naive patients aged <45 years who received two prescription fills (versus one) or a cumulative dose
of 400-799 (versus <120) morphine milligram equivalents in their first month of therapy were 2.
The high cumulative doses
used in the DOC group could have increased efficacy, but are the likely explanation for the increased risk of leucopenia associated with DOC.
The cumulative dose
of HCQ was found to be correlated with the parafoveal region thickness of OLT (r = -0.
Mean total cumulative dose
[+ or -] SD in two groups A and B were 290.
In another RCT that evaluated 48 women (average age 81 [+ or -] 8 years) with hip fracture, the same cumulative dose
of vitamin [D.
Rather radiation levels are set across the board, in order to manage an individual's cumulative dose
According to Tokyo Electric, 21 workers were exposed to a cumulative dose
of more than 100 millisieverts as of April 1.
The patients who achieved SVR received grafts from younger donors, received longer treatment duration and cumulative dose
of interferon, and had a lower drop-out rate and lower incidence of diabetes; however, there were no differences in immunosuppressive therapy for the patients.
Comment: The clinical use of cisplatin chemotherapy is limited by severe peripheral neurotoxicity, which occurs in up to 90% of patients receiving a cumulative dose
greater than 300 mg/m2 of body surface area.
The cumulative dose
to a member of the IPM clinic staff before the implementation of the new training program was 18.
Their protocol allowed three hours of this treatment with a cumulative dose
of 6 mg of flunisolide each hour, and equally aggressive albuterol dosing.
Those using the highest cumulative dose
of more than three SDDs had an 82% increased risk of cognitive decline, compared with nonusers of the medications.