Although there is a tendency to attribute the higher actual dose, higher cumulative dose
and longer duration of drug consumption to the development of retinotoxicity, the fact that shorter duration and lower dose of drug consumption may lead to development of retinotoxicity should not be ignored.
McCune noted that his study did not address those patients who are on oral cyclophosphamide, but he predicted that leuprolide treatment would be of greater merit in those patients because they generally are exposed to higher cumulative doses
In agreement with these data, our study showed a decrease in serum BGP that was correlated with the cumulative dose
Jeffrey Curtis commented in an interview that the weighted cumulative dose
model represents an advance.
Adverse events related to the corticosteroid treatment are not reduced by alternate-day administration, and there are some conflicting results about the effects of daily dose, cumulative dose
and duration of corticosteroid treatment on the rate of bone loss (4, 9).
The shorter course used slightly higher doses of radiation, but the total cumulative dose
was slightly lower.
Their usage was modest: a mean cumulative dose
According to the study authors, these patients were exposed to a mean cumulative dose
of cabergoline of 4015 mg.
Doxorubicin-induced cardiomyopathy and congestive heart failure is a well documented toxicity that appears to be dose-dependent with frequent occurrences as the cumulative dose
exceeds 550 mg/[m.
Already exposed to about twice the cumulative dose
of radiation that it was designed to handle, Galileo "is running a little bit beyond its warranty," says Johnson.
Patients treated with aldoxorubicin in this clinical trial were delivered doxorubicin in a cumulative dose
of more than 3u times the peak cumulative dose
of standard doxorubicin with no observed cardiac toxicities, even though cardiac safety is considered one of the dose-limiting side effects for standard doxorubicin.
Consider the estimated response to cumulative dose
, adjusted for sex and birth year (Table 4): For all childhood cancers we estimated an increase in risk per mSv cumulative dose