culture-negative endocarditis


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culture-negative endocarditis

Cardiology Endocarditis in which a causative microorganism are not identified

culture-negative endocarditis

Infective endocarditis produced by organisms that do not quickly or readily grow in blood cultures, usually because their growth is masked by the previous use of antibiotics or because the causative organisms require special culture media or grow slowly in the laboratory. Mycoplasma, Ricksettsia, HACEK (an acronym for Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, Kingella) organisms, and some fungi produce culture-negative endocarditis.
See: infective endocarditis
See also: endocarditis
References in periodicals archive ?
We present a case of culture-negative endocarditis and acute kidney injury due to glomerulonephritis, due to Bartonella henselae cardiac valve infection.
The Duke criteria maybe inadequate for blood culture-negative endocarditis due mainly to preceding antibiotic administration or to fastidious slow-growing organisms [6, 7].
This case serves to illustrate the potential value of PCR and DNA sequencing in diagnosing culture-negative endocarditis and the potential role of Dietzia spp.
Serological tests often give an indication of the likely pathogen in culture-negative endocarditis. Our case was complicated by positive acute serology for both Legionella spp.
We have previously reported on the impact of prior antibiotic use in culture-negative endocarditis. (18) Prior antibiotic therapy before clinical presentation (seen in 52% of our study group) was the primary contributor to the high incidence (54%) of negative blood cultures in our series.
In 1998, the patient had undergone aortic valve replacement for culture-negative endocarditis and valvular insufficiency.
Demographic and clinical features of patients with blood culture-negative endocarditis included in the study.
We obtained blood samples for cultures and then initiated empirical therapy with doxycycline and ceftriaxone for presumed common and culture-negative endocarditis pathogens.
Blood culture-negative endocarditis accounts for 2.5%-31.0% of all cases of endocarditis.
This case reinforces the hypothesis that any Bartonella species can cause human infection, including culture-negative endocarditis. Candidatus B.
Cases of culture-negative endocarditis are not routinely investigated for mycoplasmas; however, the role of these microorganisms as a cause of endocarditis might be underestimated.

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