CUL5

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CUL5

A gene on chromosome 11q22.3 that encodes cullin-5, a core protein of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate ubiquitination and subsequent proteasomal degradation of targeted proteins. Cullin-5 may contribute to catalysis by positioning the substrate and the ubiquitin-conjugating enzyme. ECS (SOCS1) may direct ubiquitination of JAK2 and be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55-kDa protein.
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References in periodicals archive ?
Workman, "E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells," Proceedings of the National Academy of Sciences of the United States of America, vol.
Then the membranes were incubated with rabbit anti-human antibodies (Cullin-5, Bip, p-ERK, ERK, and CHOP, 1:100 dilution, Invitrogen) overnight at 4[degrees]C.
The Western blotting showed that the expression of Cullin-5, a cell proliferation indicator, was higher in the [MPC.sub.5] cells treated at 33[degrees]C compared to the cells treated at 37[degrees]C (Figure 1B).
Furthermore, the Cullin-5 and Bip were down-regulated by the TM treatment in the [MPC.sub.5] cells, but their levels were increased after the HQH application for 6h (Figure 3D).