CUL1

(redirected from cullin-1)

CUL1

A gene on chromosome 7q36.1 that encodes cullin-1, a component of the multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Cullin-1 is thought to contribute to catalysis by positioning the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex depends on the neddylation of the cullin subunit, and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1.
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DT204 reduced Skp2 binding to Cullin-1 and Commd1, and synergistically enhanced bortezomib-induced apoptosis in MM cells.
It has also been reported that bacteria elicit ROS generation in epithelial cells that inactivate the Ubc12 enzyme, preventing the neddylation of cullin-1. Unneddylated cullin in E3-[SCF.sup.[beta]-TrCP] complex renders it unable to carry out ubiquitination and is thus making it inactive [171].