CUL5

(redirected from cullin 5)

CUL5

A gene on chromosome 11q22.3 that encodes cullin-5, a core protein of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate ubiquitination and subsequent proteasomal degradation of targeted proteins. Cullin-5 may contribute to catalysis by positioning the substrate and the ubiquitin-conjugating enzyme. ECS (SOCS1) may direct ubiquitination of JAK2 and be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55-kDa protein.
References in periodicals archive ?
Six mRNAs were selected that exhibited an enrichment in the Ago complexes from PCa cells and were therefore potentially downregulated in cell lines and tumors: Etoposide induced 2.4 mRNA (EI24, alias p53-induced gene 8 protein), S100 calcium binding protein A16 (S100A16), Nemo-like kinase (NLK), RAS oncogene family member 1B (RAB1B), death effector domain-containing protein (DEDD), and cullin 5 (CUL5).
Likewise, our results suggest a role for cullin 5 (CUL5) in prostate carcinoma.
The SOCS box is comprised of two functional subdomains: a BC box that recruits Elongin B and C and a Cul box that mediates Cullin 5 binding.
SOCS1 can also interact with Elongin B/C and Cullin 5 through its SOCS box, leading to ubiquitination and proteasomal degradation of target substrates [35,134],suchas JAK1 [134],JAK2 [135], TEL-JAK2 [136,137], GEF, VAV [138], insulin receptor substrate (IRS)1, and IRS-2 [139], as well the TLR2/4 adaptor protein MAL [75].