The research team found that the protein called LZTR1, in concert with its copartner cullin 3
, regulates RAS by attaching to it a small molecular tag, called ubiquitin.
The effect of Cullin 3 protein in nervous systems is yet unclear.
Anovel mutation in exon 9 of cullin 3 gene contributes to aberrant splicing in pseudohypoaldosteronism type II.
According to the human reference genome (GRCh37/hg19) from the Ensembl genome database (http://www.ensembl.org), hsa_circ_0008309 is located at chr2: 225400244-225422573 and the parental gene is Cullin 3
Under unstressed conditions, Nrf2 is kept in the cytoplasm by Kelch-like-ECH-associated protein 1 (Keap1) and Cullin 3
which induces ubiquitination of Nrf2 .
GluK2 is targeted by the Cullin 3
(Cul3) E3 ubiquitin ligase complex for ubiquitination and degradation.
Choate et al., "Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities," Nature, vol.
Zhang et al., "Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3," The Journal of Clinical Investigation, vol.
Under normal conditions, Nrf2 is kept in the cytoplasm by Kelch-like-ECH-associated protein 1 (Keap1) and Cullin 3
Nrf2 is rapidly degraded by proteasomes through the interaction with Keap1 which interacts with Cullin 3
, one of the components of ubiquitin ligase .
Santamaria et al., "Cullin 3
as a novel target in diverse pathologies," Redox Biology, vol.