CUL3

(redirected from cullin 3)

CUL3

A gene on chromosome 2q36.2 that encodes cullin-3, a core protein of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin-3 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The ubiquitin-protein ligase activity of the complex depends on neddylation of the cullin subunit, and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1.
References in periodicals archive ?
Under normal conditions, Nrf2 is sequestered in the cytoplasm by Kelch-like ECH associating protein 1 (Keap 1), a cytoskeleton binding protein, which in turn associates with Cullin 3 to form an E3 ubiquitin ligase complex that targets Nrf2 for constant proteasomal degradation [19].