Based on target prediction programs (miRTarBase, TargetScan, miRanda, and MiRBase) and published papers, we found highly evidenced candidate target genes (hypoxia-inducible factor 1A and Cullin 2
genes for hypoxia and angiogenesis; cyclin-dependent kinase 6 (CDK6), Cyclin D1 (CCND1), Cyclin E1 (CCNE1), and CCND3 genes for cell cycle) of hsa-miR-424-5p.
[sup] VHL gene encoded pVHL19 and pVHL30, which participated in the substrate recognition component of an E3 ubiquitin ligase complex that also contains elongin B, elongin C, cullin 2
, and rbx1.
miR-424 promotes angiogenesis by inhibiting cullin 2
(CUL2), thereby increasing HIF-la levels .
pombe); CHUK, conserved helix-loop-helix ubiquitous kinase; CREBBP, CREB binding protein (also known as CBP); CUL2, cullin 2
; DAPK1, death-associated protein kinase 1; DAPK2, death-associated protein kinase 2; DAPK3, death-associated protein kinase 3; DGCR8, DiGeorge syndrome critical region gene 8; DROSHA, drosha, ribonuclease type III; E2F1, E2F transcription factor 1; EGF, epidermal growth factor; EGFL7, EGF-like-domain, multiple 7; EGFR, epidermal growth factor receptor; EGLN1, egl nine homolog 1 (C.
In the Under-14 Conference, Joseph Johnson scored an incredible eight for Mount Athletic (Abdi Yousef 3, Sean Annerley 2, Jake Roper) who went goal crazy against Woolton Warriors Blue, and Warner Portcullis (Danny Cullin 2
, Chris Parle 2, Liam Parkinson, Tom Smith) beat Warner.