cubilin

cubilin

(kyūb'i-lin),
a receptor expressed in the apical endocytic apparatus of the renal proximal tubular epithelial cells and in gastrointestinal epithelium. In the gastrointestinal tract it is also referred to as intestinal intrinsic factor-cobalamin receptor. Cubilin is colocalized with megalin in the renal proximal tubular epithelium, with which it binds.
[CUB (complement components C1r/C1s, urinary epidermal growth factor, bone morphogenetic protein-1) + -ilin]
References in periodicals archive ?
Accumulation of gentamicin in proximal tubule cells is due to the existence of an apical membrane endocytic complex involving the proteins megalin and cubilin (6).
Given known interspecies differences in the functionality of megalin-associated proteins, such as cubilin, that support megalin-mediated uptake of DBP (Amsellem et al., 2010; Nielsen et al., 2016; Nykjaer et al., 2001), a move away from animal models to experimental human studies is critical.
Birn, "Megalin and cubilin: Multifunctional endocytic receptors," Nature Reviews Molecular Cell Biology, vol.
Birn, "Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease," Kidney International, vol.
Bunn et al., "Microalbuminuria in type 1 diabetes is associated with enhanced excretion of the endocytic multiligand receptors Megalin and Cubilin," Diabetes Care, vol.
In the proximal tubule of the glomerulus, apoA-I binds the receptors cubilin and megalin [28], which mediate endocytosis and delivery of the protein to the lysosomes [29, 30], resulting in complete degradation of the apoA-I protein.
Human renal proximal tubular cells in suspension culture express the endocytic scavenger proteins cubilin and megalin and the associated highly differentiated vesicular transport system not seen in 2D cultures.
[d] Excess free light chains (FLCs), readily measurable by the serum FLC assay, could disrupt the renal proximal tubule receptors megalin and cubilin where B12 is reabsorbed [5].
Steegers-Theunissen et al., "An association study of 45 folate-related genes in spina bifida: involvement of Cubilin (CUBN) and tRNA Aspartic Acid Methyltransferase 1 (TRDMT1)," Birth Defects Research A--Clinical and Molecular Teratology,vol.
Hojrup et al., "The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless," Blood, vol.
If we assume DKD with primary glomerular involvement, the increased urinary excretion of NGAL may result from disrupted mechanisms of protein transport involving megalin and cubilin, caused by long-term, excessive reabsorption of albumin in tubules [31, 32].