cryptococcal meningitis


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cryptococcal meningitis

Neurology An opportunistic infection of the meninges and spinal cord by Cryptococcus neoformans At-risk Pts AIDS, lymphoma, DM Clinical Severe headache, confusion, photosensitivity, blurred vision, fever, speech difficulties Management Amphotericin B plus flucytosine, then consolidation with fluconazole or itraconazole Prognosis Untreated, coma, death

cryptococcal meningitis

Fungal meningitis due to Cryptococcus neoformans. A rare cause of disease in healthy hosts, cryptococcal meningitis is an opportunistic infection usually seen in patients with advanced AIDS or patients taking high-dose steroids. It usually presents with gradually progressive headache and fever. The serum cryptococcal antigen test is a useful screening test. The diagnosis is established by the results of analysis and culture of cerebral spinal fluid.

Treatment

Treatment options include amphotericin B, often with flucytosine. Fluconazole and/or related antifungals are sometimes used for maintenance therapy.

See also: meningitis
References in periodicals archive ?
Cryptococcal meningitis also manifests meningitis symptoms in clinics; however, cerebral base and mater enhancement and hydrocephalus are usually not obvious or only non-enhanced colloid pseudocyst or slightly enhanced cryptococcal tumors are displayed, and sometimes expanded peripheral space of special Virchow vessels in cerebral base can be seen.
9 million people globally were living with HIV and nearly 30 years after the advent of antiretroviral therapy, opportunistic infections of the central nervous system (CNS), such as cryptococcal meningitis, cerebral toxoplasmosis, and tuberculous meningitis, are a major cause of morbidity and mortality in HIV-positive individuals (7).
Cryptococcal meningitis with accompanying recurrent cerebellitis in an immunocompetent patient.
Hidden in a headache: Cryptococcal meningitis in a septuagenarian.
Case report diagnosis of cryptococcosi and prevention of cryptococcal meningitis using a novel point-of-care lateral flow assay.
Cryptococcal meningitis and cerebral toxoplasmosis in a patient with acquired immunodeficiency syndrome.
Although incidence and mortality have decreased in the era of HAART, cryptococcal meningitis remains an important cause of mobility and mortality in the AIDS population especially in the developing world (4).
L was diagnosed with cryptococcal meningitis and treated with intravenous amphotericin B and oral flucytosine.
His medical condition deteriorated and he was diagnosed with cryptococcal meningitis with positive CSF culture.
After TB, cryptococcal meningitis is probably the most important co-infection contributing to mortality in HIV-infected adults in SA.
Prevalence and clinical presentation of cryptococcal meningitis among HIV seropositive patients.
In cryptococcal meningitis the cerebrospinal fluid examinations show an increased white blood cell count with a predominance of lymphocytes or macrophages.