May 2019 - publication of efficacy results from NIH studies using preclinical animal models evaluating MAT2203 for the treatment of cryptococcal
meningitis in the American Society for Microbiology Journal, mBio.
meningitis kills more than 180,000 people every year, 75 per cent of whom live in Sub-Saharan Africa.
Intervention: Pre-emptive anti-fungal therapy: fluconazole 800 mg/day for two weeks, then 400 mg/day for eight weeks and continued maintenance with fluconazole 200 mg/day Adults Blood cryptococcal
antigen screening positive among people with CD4 counts <100 cells/mm3 (where lumbar puncture is negative or not feasible or if lumbar puncture excludes cryptococcal
meningitis) a Conditional recommendation, low-quality evidence Adolescents Same as adults Children Not applicable since screening is not recommended Adults If HIV viral load monitoring is not available: When people are stable and adherent to ART and receiving antifungal maintenance therapy for at least one year and have a CD4 cell count [greater than or equal to] 200 cells/mm3 (two measurements six months apart).
genotype influences immunologic response and human clinical outcome after meningitis.
In the current study, we hypothesized that there are different distribution of the CNS cryptococcal
infection among non-HIV patients with and without identifiable underlying disease and the number of brain areas involved is correlated with clinical severity.
Table 1 - Cryptococcus species complex and genotype identification in the CSF samples from patients with cryptococcal
Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal
meningitis: The NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups.
Routine biochemical, hematological, and bacteriological testing including liver and kidney function tests, complete blood count, cerebrospinal fluid (CSF) examination (cytology, sugar, proteins), special staining studies (Ziehl-Nelson stain, Indian ink, etc.), chest X-ray, and (cryptococcal
and toxoplasmosis antigen with specific antigen detection tests in the serum and VDRL) were performed.
infection in a cohort of HIV-1-infected Ugandan adults.
Table 1 shows the prevalence of tuberculous meningitis and cryptococcal
meningitis in our study group.
Authors Panther and Sande (1990) augured that routine laboratory tests for cryptococcal
meningitis might appear normal, and the level of WBCs on smear may fall within the acceptable or low range (as detected in the case report result for protein and glucose of the infected patient); see Table 1.
Long, "Spectrum of neuroimaging findings in cryptococcal
meningitis in immunocompetent patients in China--A series of 18 cases," Journal of the Neurological Sciences, vol.