B, Multiple, isolated foci of acute cryptitis and small crypt abscesses
, with normal intervening mucosa (hematoxylin-eosin, original magnifications X40 [A] and X100 [B]).
Colonoscopy demonstrated multiple ulcers with severe inflammation in the descending colon (Figure 3); biopsy showed crypt abscesses and the infiltration of inflammatory cells, including neutrophils and eosinophils (Figure 4); UC was diagnosed.
There are crypt abscesses with infiltration of neutrophils and eosinophils.
2006) demonstrated an association between the deficiency of the gene MUC2 (the main gene responsible for mucin secretion in rat, mice, and humans) and the formation of crypt abscesses
and colonic inflammation.
In addition, they developed mucosal erosions and ulceration and multiple crypt abscesses
Although the visualized lesion on colonoscopy also resembled a carcinoma, biopsy showed crypt abscesses
suggestive of inflammatory bowel disease.
1-3) The histologic diagnosis of GVHD is historically based on the 1974 Lerner et al (4) criteria that qualify grade 2 GVHD as destruction of crypts with apoptotic crypt abscesses
, grade 3 GVHD as focal mucosal necrosis with denudation, and grade 4 GVHD as diffuse mucosal necrosis with denudation.
Large numbers of crypt abscesses are probably indicative of either superimposed infection or a separate diagnosis such as UC.
Be aware that some histologic features normally associated with inflammatory bowel disease, including crypt irregularity and neutrophilic cryptitis and even crypt abscesses, may be encountered in a minority of those with LC, and that the presence of one or more of these features should not necessarily be interpreted as evidence incompatible with LC.
In 2 cases reviewed (cases 7 and 8), acute cryptitis and crypt abscesses