(6, 7) Kotanagi et al (8) found that recurrence of CD at the anastomotic site did not correlate with any histologic features at the resection margin, including pyloric gland metaplasia, fibrosis, cryptitis, crypt abscesses
, ulcers, granulomas, or transmural inflammation.
He took a colonoscopy, which showed universal colitis, and a biopsy revealed crypt abscesses
and inflammatory cell infiltration and he was diagnosed with ulcerative colitis (UC).
Pathology of the sigmoid ulcer biopsy revealed focal active colitis with cryptitis, crypt abscesses
, and mild stromal lymphoplasmacytic inflammation.
Biopsies from colonoscopy revealed lymphoplasmacytic infiltrate of the lamina propria with mild architectural distortion, eosinophilic microabscesses, crypt abscesses
, and presence of larvae, representative of Strongyloides infection (Figures 3-5).
Colonoscopy demonstrated multiple ulcers with severe inflammation in the descending colon (Figure 3); biopsy showed crypt abscesses
and the infiltration of inflammatory cells, including neutrophils and eosinophils (Figure 4); UC was diagnosed.
Histological evaluation included inflammatory infiltrates, presence or absence of cryptitis and of crypt abscesses
, erosions or ulceration, and thickening of the subepithelial collagen plate.
The pathologist, who was blinded to clinical and endoscopic information, evaluated the slices for histopathological assessment of inflammation in UC, with special reference to the severity of mucosal inflammatory infiltration and the presence of crypt abscesses
and goblet cell depletion.
(2006) demonstrated an association between the deficiency of the gene MUC2 (the main gene responsible for mucin secretion in rat, mice, and humans) and the formation of crypt abscesses
and colonic inflammation.
In addition, they developed mucosal erosions and ulceration and multiple crypt abscesses
. Pathologic changes were dose and duration dependent.
Although the visualized lesion on colonoscopy also resembled a carcinoma, biopsy showed crypt abscesses
suggestive of inflammatory bowel disease.
More pronounced neutrophilic inflammation, including cryptitis and crypt abscesses
, can also be present.
Histopathological evaluation of the gastrointestinal tract revealed loss of parietal cells, mild glandular disarray, acute inflammation, and apoptotic activity in the stomach (Figure 3, hematoxylin and eosin, original magnification 200x) and patchy villous atrophy and absence of goblet cells and Paneth cells in the duodenum with crypt abscesses
and apoptosis (Figure 3, hematoxylin and eosin, original magnification 200x); and in the terminal ileum, as in the duodenum, there was also an absence of goblet and Paneth cells, with crypt dropout (Figure 3, hematoxylin and eosin, original magnification 200x).