probe

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probe

 [prōb]
1. a long, slender instrument for exploring wounds, body cavities, passages, or periodontal pockets.
Dental probes are marked in millimeters to measure the depth of periodontal pockets. From Novak, 2001.
2. a radioactive or chemiluminescent DNA or RNA fragment used to detect the presence of a complementary fragment. The labeled sequence is added to a specimen, where it forms a complex with the DNA in the sample, which has previously been treated to separate the DNA into single strands. DNA probes are used clinically to detect and identify infectious disease agents.
root canal probe in root canal therapy, an instrument for tracing the course of the root canal. Called also pathfinder, pathfinder broach, and smooth broach.

probe

(prōb),
1. A slender rod of rigid or flexible material, with a blunt bulbous tip, used for exploring sinuses, fistulae, other cavities, or wounds.
2. A device or agent used to detect or explore a substance (for example, a molecule used to detect the presence of a specific fragment of DNA or RNA or of a specific bacterial colony).
3. To enter and explore, as with a probe.
[L. probo, to test]

(Sense 2) Probes are essential tools for DNA analysis. Every DNA molecule possesses some unique nucleotide sequences that differentiate it from all others. A probe is a relatively short fabricated fragment of DNA that matches, in lock-and-key fashion, a nucleotide sequence unique to the material that is being sought. Probes are used to test for the presence of cloned genes in bacterial or yeast colonies, for specific nucleotide sequences in samples of DNA, or for specific genes on chromosomes.

probe

(prōb)
n.
1. A slender flexible surgical instrument with a blunt bulbous tip, used to explore a wound or body cavity.
2. The act of exploring or searching with a device or instrument.
3. A substance, such as DNA, that is radioactively labeled or otherwise marked and used to detect or identify another substance in a sample.

probe

Surgery Explorer A long, thin, usually metal instrument with a blunt or bulbous tip which is used to poke around in cavities, fistulae, sinuses, and wounds

probe

(prōb)
1. A slender rod of flexible material, with blunt bulbous tip, used for exploring sinuses, fistulae, other cavities, or wounds.
2. A device or agent used to detect or explore a substance, e.g., a molecule used to detect the presence of a specific fragment of DNA or RNA or of a specific bacterial colony.
3. To enter and explore, as with a probe.
[L. probo, to test]

probe

Any slender, usually blunt-ended instrument used to explore a passageway, cavity or wound.

probe

  1. a defined NUCLEIC ACID MOLECULE that can be used in MOLECULAR HYBRIDIZATION procedures to identify specific nucleic acid sequences that are complementary to it, by virtue of a LABEL generally carried by the probe. The label may be radioactive and detected by an AUTORADIO GRAPH, or non-radioactive, such as a fluorochrome, which could be detected by FLUORESCENCE. Under the right conditions the probe will hybridize only with a perfectly matching nucleic acid target molecule. The hybrid thus formed can then be detected by the appropriate method, depending upon the label on the probe. The probe may be DNA, RNA or a synthetic OLIGONUCLEOTIDE. Nucleic acid probes have a wide range of applications, such as in the detection of MICROORGANISMS in clinical specimens, in food and water samples, in the detection of genetic DISEASES (see RFLPs and in the identification of individuals (see FINGERPRINTING).
  2. a labelled molecule, such as a MONOCLONAL ANTIBODY, that can bind to a specific PROTEIN being searched for. The label permits detection.

probe

(prōb)
A slender rod of rigid or flexible material, with a blunt bulbous tip, used for exploring sinuses, fistulae, or wounds.
[L. probo, to test]
References in periodicals archive ?
Brief Overview of Cryosurgery and Cryosurgical Probes
The next generation of cryosurgical probes use a single component gas (e.g., argon) in a Joule-Thomson (JT) refrigeration cycle.
Optimization of Cryosurgical Probes for Cancer Treatment.