Therapeutic apheresis: use of human serum albumin, fresh frozen plasma and cryosupernatant
plasma in therapeutic plasma exchange.
For patients refractory to plasma exchange, the use of cryo-poor plasma (or cryosupernatant
, which is deplete of high-molecular weight vWB multimers that have a pathogenic role in TTP) may lead to a response.
Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant
The Type 3 VWD-like control can be a VWF deficient plasma, and cryosupernatant
(often available as a date-discarded blood banking product) can be used as a Type 2A-like control.
Infants or young children with familial chronic relapsing TTP generally respond well to transfusion with plasma or cryosupernatant
, which provides vWF-CP.
Consequently, the cryosupernatant
exchange was increased to 1.
Effectiveness of the cryosupernatant
fraction of plasma in the treatment of refractory thrombotic thrombocytopenic purpura.