Cryocrit is at best a crude semiquantitative method to estimate the amount of cryoprotein
Once the diagnosis of pernio is made, it is recommended to order a complete blood count to rule out blood malignancies and cryoproteins
Schmid et al., "Fibronectin in rheumatoid and non-rheumatoid arthritic synovial fluids and in synovial fluid cryoproteins
," Annals of Clinical and Laboratory Science, vol.
These may be seen in patients with cryoproteins
, lipemia, high white-blood-cell counts, and giant platelets; and
Kaplan ME: Cryoglobulinemia in infectious mononucleosis: Quantitation and characterization of the cryoproteins
. J Lab Clin Med 1968: 71:754-764
are serum proteins that reversibly precipitate at temperatures below 37 [degrees]C.
Q Our reference laboratory recommends that whole-blood specimens for automated blood counts collected in EDTA be maintained at room temperature during transit because refrigeration may precipitate cryoproteins
, which trap leukocytes and platelets, resulting in spurious lowered counts.