cryoprecipitates


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Related to cryoprecipitates: fresh frozen plasma

cryoprecipitates

Substances isolated or purified from a solution by lowering the temperature or by freezing and then thawing. Cryoglobulin is demonstrated, and the antihaemophilic factor, Factor VIII, is obtained, in this way from blood plasma.
References in periodicals archive ?
All cryoprecipitates should be characterized for the presence of monoclonal components.
All laboratories performed visual observation of the cryoprecipitate. Most laboratories (72%) compared the same sample at different temperatures and approximately 1 in 3 laboratories (32%) compared serum and plasma.
There was wide variation in the type of results reported, ranging from a simple qualitative negative/positive result to a quantitative report including cryoglobulin type and total protein content and/or immunoglobulin concentration in the cryoprecipitate. Of the 127 laboratories included for the postidentification phase, 50 (39%) reported the cryocrit, the total protein content, and/or the immunoglobulin concentration in the cryoprecipitate (quantitative); 48 (38%) answered negative/ positive only; and 29 (23%) provided additional information without reporting the cryoglobulin concentration in the cryoprecipitate (nonquantitative).
Forty-six of the 50 laboratories that provided a quantitative report and 55 of the 77 laboratories that provided a nonquantitative report performed immunofixation analysis on the cryoprecipitate. Of the 101 laboratories (57%) that further immunotyped the cryoprecipitate, 98 performed immunofixation or immunoelectrophoresis, and 3 used protein electrophoresis only.
For type I cryoglobulins, which are often present at concentrations >5 g/L, (1), reporting the presence or absence of an important visual cryoprecipitate that can be resolubilized is acceptable.
Of the 11 laboratories that provided reference values, only 3 (2%) applied cryoprecipitate-specific reference values, whereas the other 8 used reference values for serum proteins and/or immunoglobulins, which are not valid for the cryoprecipitate. Three laboratories that had cryoprecipitate-specific reference values provided different reference values using total protein content: 0-10 mg/L serum (no reference provided), 0-50 mg/L serum (no reference provided), and 0-80 mg/L (12).
Although several authors have looked at total protein content in the cryoprecipitate to establish reference values, (12, 14, 15), only 3 laboratories (2%) provided cryoprecipitate-specific reference values for total protein content.