cryoglobulinemia


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cryoglobulinemia

 [kri″o-glob″u-lin-e´me-ah]
the presence of cryoglobulin in the blood, associated with a variety of clinical manifestations including Raynaud's phenomenon, vascular purpura, cold urticaria, necrosis of extremities, bleeding disorders, vasculitis, arthralgia, neurologic manifestations, hepatosplenomegaly, and glomerulonephritis.

cry·o·glob·u·lin·e·mi·a

(krī'ō-glob'yū-li-nē'mē-ă),
The presence of abnormal quantities of cryoglobulin in the blood plasma.

cryoglobulinemia

Primary cryoglobulinemia Hematology A condition caused by proteins that precipitate in vivo on cooling of acral parts, which are often associated with immune complex-related disease; cryoglobulinemia has been divided into 3 clinical forms Clinical Pain, cyanosis, arthralgias, vascular purpuras, cold intolerance, HTN, CHF Lab ↓ C4 and other complement proteins
Cryoglobulinemia
Type I Monoclonal cryoglobulinemia Underlying disease is often malignant; IgG (malignant myeloma), IgM macroglobulinemia or lymphoma/CLL, rarely others (eg IgA nephropathy), benign monoclonal gammopathy
Type II Poly-monoclonal cryoglobulinemia A complex of immunoglobulins, eg mixed IgM-IgG, G-G, A-G or other combinations that may be associated with lymphoreticular disease or connective tissue disease (rheumatoid arthritis, Sjögren syndrome, mixed essential cryoglobulinemia)
Type III Mixed polyclonal-polyclonal cryoglobulinemia Mixed IgG & IgM, ± IgA, due to rheumatoid arthritis, SLE, Sjögren syndrome, EBV, CMV, subacute bacterial infections, poststreptococcal, crescentic and membranoproliferative glomerulonephritides, DM, chronic hepatitis, biliary cirrhosis

cry·o·glob·u·lin·e·mi·a

(krī'ō-glob'yū-li-nē'mē-ă)
The presence of abnormal quantities of cryoglobulin in blood plasma.
Synonym(s): cryoglobulinaemia.

Cryoglobulinemia

Condition in which protein in the blood forms particles in the cold, blocking blood vessels and leading to pain and numbness of the extremities.
References in periodicals archive ?
We concluded that liver histology should be performed in untreated HCV carriers that are seropositive for either smooth muscle antibodies or cryoglobulinemia.
Absence of antibodies to cyclic citrullinated peptide in sera of patients with hepatitis C infection and cryoglobulinemia. Arthritis Rheum 2004; 50: 2305-8.
Other entities that have been reported in association with DAH include primary antiphospholipid antibody syndrome, mixed cryoglobulinemia, Behcet syndrome, and Henoch-Schonlein purpura along with some drug reactions and some infections (human immunodeficiency virus, listeriosis).
Although macroenzymes have been reported to be associated with autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, cryoglobulinemia, and inflammatory bowel disease, there is no convincing evidence of antienzyme antibodies causing disease (5-8), although some antienzyme antibodies (such as antithyroid peroxidase and anti-LKM1) are considered markers of autoimmune diseases.
Rheumatic symptoms associated with HCV may represent essential mixed cryoglobulinemia (J.
Over the past 3 years, several high-profile gastroenterologists and dermatologists have called for routine HCV screening in patients with nonfamilial porphyria cutanea tarda or small-vessel vasculitis caused by essential mixed cryoglobulinemia (types II and III).
Our study is limited by a lack of cryoglobulinemia testing (due to technical reasons), which is an independent factor of sensorimotor neuropathy and mononeuritis multiplex.
Hepatitis A Virus: Jaundice rarely cryoglobulinemia and vasculitis.
Cryoglobulinemia is associated with Raynaud's phenomenon, cold urticaria, dizziness, and epistaxis; it is also associated with hepatitis C infection in >90% of cases.
In the 1960s, using transmission electron microscopy, a recently introduced diagnostic tool, Drs Gallo and Helen Feiner published an elegant study of deposits associated with cryoglobulinemia. Dr Gallo also pioneered ultrastructural studies on nodular glomerulopathy associated with nonamyloidotic [kappa] light-chain deposits and immunolabeling of amyloid fibrils as well as the amyloidlike fibrils of fibrillary glomerulopathy.
In the setting of a chronic, untreated HCV infection and evidence of nephrotic syndrome, a cryocrit was requested to investigate the possibility of membranoproliferative glomerulonephritis secondary to cryoglobulinemia. A renal biopsy demonstrated diffuse, proliferative glomerulonephritis and immune-complex deposits.