crossover trial


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crossover trial

A clinical trial design in which subjects act as their own control and are assigned to receive investigational product and controls in an order determined by randomisations, with a washout period between the two epochs.

crossover trial

A scientific study of a therapeutic agent in which participants are exposed in sequence to the putative cure and subsequently (or previously) to an inactive agent or an agent whose efficacy has been previously established. The participants cross over from one arm of the study to the other and serve as their own control group.

Participants in such trials are usually under the care of a team of physicians and nurses and are closely monitored, often with testing and examinations on a weekly basis. The clinical trial nurse or nurse research specialist has a broad variety of roles, depending on the nature of the investigation. The roles include recruiting and introducing patients to the trial, coordinating their care, gathering data about side effects and tolerance, and, frequently, serving as a principal or collaborative investigator. Trial planning and design, data interpretation and analysis, and assessments of toxicity are all elements of the work. Health insurers and managed care providers may place restrictions on clinical trial coverage. Many states have laws requiring insurers to pay for the routine costs of all or some clinical trials. Patient advocates work with researchers to make sure a clinical trial is relevant, as safe as possible, and accessible to the broadest variety of patients.

Synonym: crossover (2)
See also: trial
References in periodicals archive ?
Moderate evidence--According to a randomized crossover trial by Coleman et al.
The following linear model was used to analyze the crossover trial (29):
The acceptability of the female and male condom: a randomized crossover trial, Perspectives on Sexual and Reproductive Health, 2004, 36(3):114-119.
RANDOMISED CROSSOVER TRIAL OF TRANSDERMAL FENTANYL AND SUSTAINED RELEASE ORAL MORPHINE FOR TREATING CHRONIC NON-CANCER PAIN
15] Jacobsson et al published the results of a double-blind, placebo-controlled, crossover trial of budesonide.
The students, all regular coffee drinkers, were given grapefruit juice with or without caffeine during two different medical school exams in a double blind, placebo-controlled, randomized crossover trial.
Robust evidence--Based on the results from a randomized crossover trial, Board et al.
The human abuse liability trial study is a double-blind, randomised, active- and placebo-controlled four-way crossover trial that will assess the abuse potential of I.
METHODS: In a randomized, double-blind, crossover trial, we evaluated gastrointestinal symptoms in 30 people (mean age, 29.
A multicenter, open-label crossover trial involving 66 women with a history of breast cancer who had at least 14 hot flashes per week evaluated patient preference when treated with extended-release venlafaxine 75 mg daily and gabapentin 300 mg rid, each for 1 month.
At the congress, she presented a secondary analysis of data from a published, double-blind, randomized, multicenter crossover trial of frovatriptan (Frova) versus almotriptan (Axert) for the acute treatment of migraine (J.
Canned soup consumption and urinary bisphenol A: a randomized crossover trial.