cross-tolerance

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cross-tolerance

[kros´tol-er-ans]

extension of the tolerance for a substance to others of the same class, even those to which the body has not been exposed previously.

cross-tolerance

(krôs′tŏl′ər-əns, krŏs′-)

Tolerance or resistance to an effect or effects of a compound as a result of tolerance previously developed to a pharmacologically similar compound.

cross-tol·er·ance

(kraws tol'ĕr-ăns)

The resistance to one or more effects of a compound as a result of tolerance developed to a pharmacologically similar compound.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cross-tol·er·ance

(kraws tol'ĕr-ăns)

Resistance to one or several effects of a compound as a result of tolerance developed to a pharmacologically similar compound.

Medical Dictionary for the Dental Professions © Farlex 2012

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Due to the observation that A20 is a key molecule in the establishment of TNF/LPS cross-tolerance [6], its importance within TNF tolerance has also been assessed.

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Framework of Addiction Interaction Disorders (1) Cross-tolerance (a) "A simultaneous increase of addictive behaviour in two or more addictions", or (b) when one addictive behaviour is substituted for another and there is a higher-than-expected tolerance for the new behaviour.

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Chronic alcohol treatment can produce not only tolerance to the effects of alcohol but also cross-tolerance to the effects of nicotine.

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This illustrates that, under the range of operating conditions used in this study, cross-tolerance is insignificant in predicting viability loss.

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As mentioned earlier, acclimation to some stresses has also been found to provide cross-tolerance to other stresses.

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The sedative-hypnotic drugs, including alcohol and benzodiazepines, have cross-tolerance and dependence to one another so that any may be substituted for the other.

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Finally, to gain insights into the cytokine patterns and potential cross-tolerance, the effect of LTA pretreatment was examined in CpG/D-galN and R848/D-galN mice.

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Another mechanism that may contribute to alcohol-nicotine interactions is cross-tolerance to the effects of both drugs.

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Different opioids bind slightly differently to receptors, and incomplete cross-tolerance is common, she noted.

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These mechanisms include genes that are involved in regulating certain brain chemical systems; neurobiological mechanisms, such as cross-tolerance and cross-sensitization to both drugs; conditioning mechanisms, in which cravings for alcohol or nicotine are elicited by certain environmental cues; and psychosocial factors (e.g., personality characteristics and coexisting psychiatric disorders).