cross-resistance


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resistance

 [re-zis´tans]
1. opposition, or counteracting force, as opposition of a conductor to passage of electricity or other energy or substance.
2. the natural ability of a normal organism to remain unaffected by noxious agents in its environment; see also immunity.
3. in psychology or psychiatry, conscious or unconscious defenses against change, preventing repressed material from coming into awareness; they can take such forms as forgetfulness, evasions, embarrassment, mental blocks, denial, anger, superficial talk, intellectualization, or intensification of symptoms. It occurs because the blocked association or understanding would be too threatening to face at this point in the therapy; identification of what point the resistance comes at can be an important indicator of the patient's unconscious patterns.
airway resistance the opposition of the tissues of the air passages to air flow: the mouth-to-alveoli pressure difference divided by the rate of air flow. Symbol RA or RAW.
androgen resistance resistance of target organs to the action of androgens, resulting in any of a spectrum of defects from a normal male phenotype in which men have normal genitalia but infertility to complete androgen resistance in which the individual has a female phenotype. Complete androgen resistance is an extreme form of male pseudohermaphroditism in which the individual is phenotypically female but is of XY chromosomal sex; there may be rudimentary uterus and tubes, but the gonads are typically testes, which may be abdominal or inguinal in position. Called also testicular feminization and testicular feminization syndrome. Incomplete androgen resistance is any of various forms less than the complete type, manifested by a male phenotype with various degrees of ambiguous genitalia such as hypospadias and a small vaginal pouch, a hooded phallus, or a bifid scrotum that may or may not contain gonads.
drug resistance the ability of a microorganism to withstand the effects of a drug that are lethal to most members of its species.
insulin resistance see insulin resistance.
multidrug resistance (multiple drug resistance) a phenomenon seen in some malignant cell lines: cells that have developed natural resistance to a single cytotoxic compound are also resistant to structurally unrelated chemotherapy agents. Called also cross-resistance.
peripheral resistance resistance to the passage of blood through the small blood vessels, especially the arterioles.
pulmonary vascular resistance the vascular resistance of the pulmonary circulation; the difference between the mean pulmonary arterial pressure and the left atrial filling pressure divided by the cardiac output. Called also total pulmonary vascular resistance.
total peripheral resistance the vascular resistance of the systemic circulation: the difference between the mean arterial pressure and central venous pressure divided by the cardiac output.
total pulmonary resistance (total pulmonary vascular resistance) pulmonary vascular resistance.
vascular resistance the opposition to blood flow in a vascular bed; the pressure drop across the bed divided by the blood flow, conventionally expressed in peripheral resistance units. Symbol R or R.

cross-resistance

/cross-re·sis·tance/ (kros-re-zis´tans) multidrug resistance.

cross-resistance

(krôs′rĭ-zĭs′təns, krŏs′-)
n.
Tolerance to a usually toxic substance as a result of exposure to a similarly acting substance: Some insects develop cross-resistance to insecticides.

cross-resistance

resistance to a particular antibiotic that often results in resistance to other antibiotics, usually from a similar chemical class, to which the bacteria may not have been exposed. Cross-resistance can occur, for example, to both colistin and polymyxin B or to both clindamycin and lincomycin.

cross-re·sis·tance

(kraws rĕ-zistăns)
Resistance to one agent or drug that confers resistance to another, usually similar agent.

cross-resistance,

References in periodicals archive ?
The fluoroquinolone-resistant strains in recurrent P aeruginosa infection showed high cross-resistance to other drugs.
Selection of a field population of diamondback moth (Lepidoptera: Plutellidae) with acetamiprid maintains, but does not increase, cross-resistance to pyrethroids.
Cross-resistance and collateral sensitivity of drug-resistant cell lines
Cross-resistance and genetics of resistance to indoxacarb in Spodoptera litura (Lepidoptera: Noctuidae), J.
The low cross-resistance to tetracycline among CRKP and stable resistance rate of K.
Early failure of a first regimen--there is unlikely to be much cross-resistance.
It appears that alterations in the membrane fluidity of the acid-tolerant strains might confer cross-resistance to other stresses.
Several possible mechanisms are reviewed that could explain the partial lack of cross-resistance including type of previous therapy, biological characteristics of tumour, pharmacological efficacy of the different AIs, bioavailability of AIs in tumour tissue, aromatase enzyme variants and different promoters, and the importance of the irreversibility of AIs such as exemestane or its partial androgen agonistic effects.
These strains of measles virus are used as therapeutic agents against cancer that demonstrates no cross-resistance with existing treatment approaches, and can therefore be combined with conventional treatment methods.
As there are limited options for those who develop resistance to all three major antiretroviral drug classes, it is particularly important that new agents are developed with novel mechanisms of action, as these will be unlikely to display cross-resistance with existing agents [7].
Linezolid--ADULT--600 mg every 12 h iv or 600 mg twice per day po--CHILDREN--10 mg/kg every 12 h iv or po Bacteriostatic; limited clinical experience; no cross-resistance with other antibiotic classes; expensive; may eventually replace other second-line agents as a preferred agent for oral therapy of MRSA infections"