crocin


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crocin

Pharmacognosy
A mixture of two flavonol glycosides, crocetin (a carotenoid-dicarboxylic acid) and alpha-crocin (a di-gentiobiose ester of crocetin), which are abundant in the stigmas and styles of saffron (Crocus sativus) flowers and have a prostaglandin-like structure. Intramuscular injection of crocetin in rabbits increases oxygen diffusion in plasma, and reduces serum cholesterol and the incidence of atherosclerosis.
References in periodicals archive ?
(100) demonstrated one month administration of 20 mg/day crocin had no significant effect on haematological, biochemical, hormonal or urinary parameters in healthy adults.
Numerous studies have demonstrated that treatment with antioxidant substances such as vitamins E and C, (34) N-acetyl-cysteine, (10) crocin and safranal, (11) and selenium (38) can decrease oxidative stress and mortality rates related to OPI-induced toxicity.
10.21 mg Crocin I was accurately weighed and placed in a 100 ml volumetric flask, dissolved in methanol and diluted to volume.
The color of saffron is mostly due to the carotenoid named crocin, which is considered among the active principles mostly responsible for neuroprotective activity [54].
Natural products such as crocin isolated from Crocus sativus have been proved significantly effective in ameliorating liver injury via downregulating markers of proinflammation and fibrosis [75].
jasminoides extracts and their main active phytoconstituents geniposide, genipin, crocin, crocetin have been reported for a wide range of pharmacological activities such as anti-hyperglycemic, anti-atherosclerotic, anti-inflammatory, anti-arthritis, and anti-cancer etc.
Its major constituents include crocin, crocetin, safranal can also be classified as antioxidants and share structural similarities with other antioxidants, such as zeaxanthin.
According to the reaction mechanism these assays are divided into two broad categories: Hydrogen atom transfer assay (HAT) such as inhibition of induced LDL auto-oxidation, oxygen radical absorbance capacity (ORAC), total radical trapping antioxidant parameter (TRAP), crocin bleaching assays and electron transfer assay (ETA) that includes the TPC assay by the Folin reagent, Trolox equivalence antioxidant capacity (TEAC), ferric ion (Fe3+) reducing antioxidant power (FRAP), "total antioxidant potential" assay where Cu(II) complex captures electrons, and DPPH assay.
Protective effect of crocin on diazinon induced vascular toxicity in subchronic exposure in rat aorta ex-vivo.
or saffron [Iridaceae family] has four major pharmacologically active constituents such as crocin, crocetin, picrocrocin, and safranal.
Crocin is a main active compound isolated from Crocus sativus L.