creatine phosphokinase

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Related to creatine phosphokinase: troponin

cre·a·tine ki·nase (CK),

an enzyme catalyzing the reversible transfer of phosphate from phosphocreatine to ADP, forming creatine and ATP; of importance in muscle contraction. Certain isozymes are elevated in plasma following myocardial infarctions.

creatine phosphokinase


a nonprotein nitrogen substance synthesized in the body from three amino acids: arginine, glycine (aminoacetic acid) and methionine. Creatine readily combines with phosphate to form phosphocreatine, or creatine phosphate, which is present in muscle, where it serves as the storage form of high-energy phosphate necessary for intense muscle contraction.

creatine kinase (CK)
an organ-specific enzyme catalyzing the transfer of a phosphate group from phosphocreatine to ATP. It has three isoenzymes: CK1, found primarily in the brain; CK2, found in the myocardium; and CK3, found in both skeletal muscle and the myocardium. In humans, the presence of CK2 in the blood is useful in diagnosing a recent myocardial infarction, but in animals CK3 is most commonly increased related to muscle damage. Called also creatine phosphokinase, Lohmann's enzyme.
creatine phosphate
see creatine (above).
creatine phosphokinase
called also CPK; see creatine kinase (above).
References in periodicals archive ?
Specificity of elevated serum MB creatine phosphokinase activity in the diagnosis of acute myocardial infarction.
Table 3 Effect of PYCNOGENOL[R] on the elevated creatine phosphokinase (CPK) activity induced by Dox in mice.
8 C-reactive protein, mg/L 27 7 4 Creatine phosphokinase, mg/L 12,159 12,918 10,937 Aspartate aminotransferase, IU/L 161 203 169 Alanine aminotransferase, IU/L 83 205 284 Lactate dehydrogenase, IU/L 691 553 451 Creatinine, [micro]mol/L 31.
The key points regarding this necrotizing myopathy: It features proximal muscle weakness and an elevated creatine phosphokinase (CPK) arising during statin therapy that persist after the drug is stopped, and a muscle biopsy showing necrosis and myophagocytosis but no significant inflammation.
Elevations in creatine phosphokinase can be caused by strenuous activity, trauma, prolonged muscle cramps, generalized seizures, myopathies, postsurgery, hypothyroidism, pulmonary embolism, myocardial infarction, myocarditis, and rhabdomyolysis.
Blood chemistry values included raised enzymes: 1,858 IU/L lactate dehydrogenase (LDH), 283 IU/L aspartate aminotransferase (AST), 210 IU/L alanine aminotransferase (ALT), 672 IU/L creatine phosphokinase, and 84 IU/L [gamma]-glutamyl transaminase.
Patients need to be monitored for creatine phosphokinase changes and for muscle pain or weakness.
Also, within normal limits were antinuclear antibodies, rheumatoid factor, creatine phosphokinase, liver function tests, and thyroid-stimulating hormone.
Clinical significance of low creatine phosphokinase values in patients with connective tissue diseases.
Common adverse events of all grades were consistent with single agent data reported for the MEK inhibitor class and included rash, diarrhea, acneiform dermatitis, edema, creatine phosphokinase elevation, central serous retinopathy-like events, nausea, and fatigue.
Current labeling advises physicians to monitor creatine phosphokinase levels weekly and to consider discontinuing statins.
Other common abnormal laboratory findings include elevated lactate dehydrogenase levels in 70% to 90% of patients (11,18,19), elevated alanine aminotransferase of aspartate aminotransferase levels in 20% to 30% (11,22), elevated creatine phosphokinase in 30% to 40% (11,22,30), and elevated C-reactive protein (1,31).

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