creatine phosphokinase

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Related to creatine phosphokinase: troponin

cre·a·tine ki·nase (CK),

an enzyme catalyzing the reversible transfer of phosphate from phosphocreatine to ADP, forming creatine and ATP; of importance in muscle contraction. Certain isozymes are elevated in plasma following myocardial infarctions.

creatine phosphokinase


a nonprotein nitrogen substance synthesized in the body from three amino acids: arginine, glycine (aminoacetic acid) and methionine. Creatine readily combines with phosphate to form phosphocreatine, or creatine phosphate, which is present in muscle, where it serves as the storage form of high-energy phosphate necessary for intense muscle contraction.

creatine kinase (CK)
an organ-specific enzyme catalyzing the transfer of a phosphate group from phosphocreatine to ATP. It has three isoenzymes: CK1, found primarily in the brain; CK2, found in the myocardium; and CK3, found in both skeletal muscle and the myocardium. In humans, the presence of CK2 in the blood is useful in diagnosing a recent myocardial infarction, but in animals CK3 is most commonly increased related to muscle damage. Called also creatine phosphokinase, Lohmann's enzyme.
creatine phosphate
see creatine (above).
creatine phosphokinase
called also CPK; see creatine kinase (above).
References in periodicals archive ?
The importance of serum creatine phosphokinase level in the early diagnosis and microbiological evaluation of necrotizing fasciitis.
CPKMB = creatine phosphokinase-MB; TCPK = total creatine phosphokinase.
By day 4 of hospitalization, the patient's level of creatine phosphokinase had elevated to 146 266 U/L, the level of aspartate aminotransferase was 3082 U/L, the level of alanine aminotransferase was 1144 U/L, and the level of lactate dehydrogenase was 4687 U/L.
This study reports the case of a woman with severe asthenia and very high blood levels of creatine phosphokinase and lactate dehydrogenase.
We report the case of a woman with severe asthenia and very high blood levels of creatine phosphokinase and lactate dehydrogenase.
14,58) Studies show that HMB supplementation may significantly lower serum lactate dehydrogenase (LDH), lower serum creatine phosphokinase (CPK) levels and delay blood lactate accumulation after endurance training compared to placebo.
Early in the respiratory phase, elevated creatine phosphokinase levels (as high as 3,000 IU/L) and hepatic transaminases (two to six times the upper limits of normal) have been noted.
One of these enzymes was creatine phosphokinase (CPK), which plays a major role in intracellular energy transport from mitochondria to myofibrils, and in the regulation of energy production coupled to energy utilization.
A 5-mL blood sample for creatine phosphokinase (CPK) and aldolase levels was obtained before and 5 to 7 days after vaccination.
Chronic supplementation with antioxidants can overcome this muscle damage as evidenced by suppression of creatine phosphokinase release.

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