creatine kinases

creatine kinases (CKs)

Enzymes that catalyze the bond between creatine and ATP to form creatine phosphate and ADP with the storage of energy in the phosphate bond. Creatine phosphate occurs mainly in muscle and contributes energy required for muscle contraction. CKs are released into the blood from damaged heart and other muscle cells. Creatine kinase estimations are important in the diagnosis and quantification of heart muscle damage or death after CORONARY THROMBOSIS. CK blood levels rise after strenuous exercise or intramuscular injections.
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Characteristics of mitochondrial creatine kinases from normal human heart and liver tissues.
Creatine kinase [(CK)[5]; EC2.7.3.2] is an 82-kDa protein consisting of two subunits, CK-muscle (CK-M) and -brain (CK-B).
The first report of a case with acute myocardial infarction showing familial deficiency of creatine kinase. Intern Med 1992;31:611-6.
Stability of macro creatine kinases and creatine kinase isoenzymes compared: heat inactivation test for determination of thermostable creatine kinases.
In patients with acute myocardial infarction (AMI), the activity of creatine kinase isoenzyme MB (CKMB) in plasma consistently accounts for ~15% of the total CK activity (1, 2).
The creatine kinase system in normal and diseased human myocardium.
Proposed clinical syndrome definitions are myalgia (muscle weakness or ache with normal creatine kinase), myositis (symptoms with increased creatine kinase), and rhabdomyolysis (symptoms, markedly elevated creatine kinase, and renal insufficiency) as subsets of the more general term myopathy.
A large well-done British epidemiologic cohort study (n=96,193) found an increased rate of myopathy (broadly defined, not requiring creatine kinase elevation) among patients taking statins, with an absolute rate difference of 1 per 10,000 person-years.
(8) In the AFCAPS/TexCAPS trial, 20 of 21 statin patients (out of a study population of 3304) who had elevated creatine kinase (>10 times the upper limits of normal) recovered with continued lovastatin treatment, while the other patient resumed treatment after a brief interruption without further elevations.
Corresponding phosphagen (guanidino) kinases - arginine kinase [AK], creatine kinase [CK], glycocyamine kinase [GK], taurocyamine kinase [TK], hypotaurocyamine kinase [HTK] and lombricine kinase [LK] - catalyze the reversible transfer of phosphate from phosphagen to ADP, yielding ATP (phosphagen + ADP [implies] ATP + guanidine acceptor).
(1985) showed that sea urchin spermatozoa contain creatine kinase (CK) and that sustained swimming is highly dependent on CK activity, presumably due to its role in energy transport.
Functions of creatine kinase isoenzymes in spermatozoa.

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