creatine kinase isoenzymes

cre·a·tine ki·nase i·so·en·zymes

the isoenzymes of creatine kinase. Creatine kinase is a dimer with M (muscle) and/or B (brain) subunits; it exists in three isoenzyme forms: CK-MM, the predominant form, found primarily in skeletal muscle; CK-MB, found in cardiac muscle, tongue, diaphragm, and in small amounts in skeletal muscle; and CK-BB found in the brain, smooth muscle, thyroid, lungs, and prostate. Elevations detected by electrophoresis or other methodologies can be used to help in the differential diagnosis of a variety of disease states, with CK-MB elevations as an important marker following myocardial infarctions, elevations in CK-MM an indicator of muscle disease, and increases in CK-BB an occasional finding following brain infarcts, bowel infarcts, or in the presence of certain malignancies.
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References in periodicals archive ?
Serum creatine kinase isoenzymes in Duchenne muscular dystrophy determined by sensitive enzyme immunoassay methods.
Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the phosphocreatine circuit for cellular energy homeostasis.
Creatine kinase isoenzymes in extracts of various human skeletal muscles.
Rapid separation of plasma creatine kinase isoenzymes by batch adsorption on glass beads.
Creatine kinase isoenzymes. New York: Springer-Verlag, 1981:317pp.
Creatine kinase isoenzymes of mitochondrial origin in human serum.
Stability of macro creatine kinases and creatine kinase isoenzymes compared: heat inactivation test for determination of thermostable creatine kinases.
Profile of creatine kinase isoenzymes in skeletal muscle of marathon runners.