creatine kinase


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Related to creatine kinase: creatinine, Creatine Kinase Test

creatine

 [kre´ah-tin]
a nonprotein substance synthesized in the body from three amino acids: arginine, glycine (aminoacetic acid), and methionine. Creatine readily combines with phosphate to form phosphocreatine, or creatine phosphate, which is present in muscle, where it serves as the storage form of high-energy phosphate necessary for muscle contraction.
creatine kinase an enzyme catalyzing the transfer of a phosphate group from phosphocreatine to ATP. It has three isoenzymes: CK1, found primarily in the brain; CK2, found in the myocardium; and CK3, found in both skeletal muscle and the myocardium. The presence of CK2 in the blood is strongly indicative of a recent myocardial infarction; it is present until about 72 hours after the attack.

cre·a·tine ki·nase (CK),

an enzyme catalyzing the reversible transfer of phosphate from phosphocreatine to ADP, forming creatine and ATP; of importance in muscle contraction. Certain isozymes are elevated in plasma following myocardial infarctions.

creatine kinase

/cre·a·tine ki·nase/ (ki´nās) an enzyme that catalyzes the phosphorylation of creatine by ATP to form phosphocreatine. It occurs as three isozymes (specific to brain, cardiac muscle, and skeletal muscle, respectively), each having two components composed of M (muscle) and/or B (brain) subunits. Differential determination of isozymes is used in clinical diagnosis.

creatine kinase

n.
An enzyme present in muscle, brain, and other tissues of vertebrates that catalyzes the reversible conversion of ADP and phosphocreatine into ATP and creatine.

creatine kinase (CK)

an enzyme of the transferase class in muscle, brain, and other tissues. It catalyzes the transfer of a phosphate group from adenosine triphosphate to creatine, producing adenosine diphosphate and phosphocreatine. The reaction stores energy in muscle and brain tissue. Also called creatine phosphokinase. See also Duchenne's muscular dystrophy.

creatine kinase

Creatine phosphokinase Internal medicine An 82 kD dimeric enzyme that catalyzes the reaction ATP + creatine = ADP + phosphocreatine, which exchanges high-energy phosphate and consumes energy; CK is concentrated in skeletal muscle, heart, brain; since CK levels peak 12-24 hrs after an MI and returns to normal by 48 hrs, specimen timing is critical Ref range 0-250 U/L. See Creatinine kinase isoenzymes.

cre·a·tine ki·nase

(CK) (krē'ă-tin kī'nās)
An enzyme catalyzing the reversible transfer of phosphate from phosphocreatine to ADP, forming creatine and ATP; of importance in muscle contraction. Certain isozymes are elevated in plasma following myocardial infarctions.

creatine kinase

muscle tissue enzyme catalysing phosphate (PO42-) transfer, to allow reformation of adenosine triphosphate (ATP) from adenosine diphosphate (ADP)

cre·a·tine ki·nase

(CK) (krē'ă-tin kī'nās)
An enzyme catalyzing the reversible transfer of phosphate from phosphocreatine to adenosine diphosphate, forming creatine and adenosine triphosphate.

creatine kinase (krē´ətēn´ kī´nās´),

n an enzyme in muscle, brain, and other tissues that catalyzes the transfer of a phosphate group from adenosine triphosphate to creatine, producing adenosine diphosphate and phosphocreatine.
References in periodicals archive ?
The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches.
2015) showed that after 50 eccentric contractions of the elbow flexors, the use of Theracurmin before and 12h after the exercise significantly reduced the loss of strength of the elbow flexors immediately post-exercise, although there was no effect on creatine kinase blood concentration measured at 48h, 72h and 96h after the exercise.
Elevation of blood creatine kinase and selected blood parameters after exercise in thoroughbred racehorses (Equus caballus L).
Disposition of creatine kinase activity in dog plasma following intra-venous and intramuscular injection of skeletal muscle homogenates.
The effect of caffeine consumption on serum creatine kinase levels after eccentric exercise was measured.
One way to determine the damage in skeletal muscle is to analyze creatine kinase activity (18).
In the presence of muscle injury, sodium and calcium are released into intracellular space, while potassium, phosphate, urate, myoglobin, and creatine kinase move into circulation (Criddle, 2003).
Aspartate aminotransferase, calcium, creatine kinase, lactate dehydrogenase, total protein, triglycerides, and uric acid in plasma were determined by a commercial laboratory (Vet Pro Labs, Tulsa, Oklahoma).
In summary, we have shown that a medical student considered to be MH positive on muscle biopsy testing can safely be present in an operating theatre and exposed to low concentrations of volatile anaesthetics, with no clinical ill effects but with subclinical elevations of creatine kinase above the reference range.
In her study, conducted with eighty well trained marathon runners, Parker found that post-race levels of creatine kinase were thirty to fifty percent higher in the group of runners that were using statins to treat high cholesterol when compared to a control group (runners not using statins).