creatine


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creatine

 [kre´ah-tin]
a nonprotein substance synthesized in the body from three amino acids: arginine, glycine (aminoacetic acid), and methionine. Creatine readily combines with phosphate to form phosphocreatine, or creatine phosphate, which is present in muscle, where it serves as the storage form of high-energy phosphate necessary for muscle contraction.
creatine kinase an enzyme catalyzing the transfer of a phosphate group from phosphocreatine to ATP. It has three isoenzymes: CK1, found primarily in the brain; CK2, found in the myocardium; and CK3, found in both skeletal muscle and the myocardium. The presence of CK2 in the blood is strongly indicative of a recent myocardial infarction; it is present until about 72 hours after the attack.

cre·a·tine

(krē'ă-tēn, -tin), Do not confue this word with creatinine.
A compound, N-(aminoiminomethyl)-N-methylglycine, which occurs in urine, sometimes simply as creatine, but generally as creatinine, and in muscle, generally as phosphocreatine. Elevated levels are found in the urine of individuals with muscular dystrophy.

creatine

(krē′ə-tēn′, -tĭn) also

creatin

(-tĭn)
n.
A compound, C4H9N3O2, that is found in the muscle tissue of vertebrates mainly in the form of phosphocreatine and that is involved in storing and supplying energy for muscle contraction.

cre·a·tine

(krē'ă-tin)
N-(aminoiminomethyl) - N-methylglycine; occurs in urine, sometimes as such, but generally as creatinine, and in muscle, generally as phosphocreatine; elevated in urine in muscular dystrophy; synthesized in liver and pancreas from amino acids; absorbed in bloodstream, it is deposited in tissue (e.g., muscles, brain).

creatine

A nitrogenous substance present in all muscle cells.

creatine

a white nitrogenous substance found in vertebrate muscles.

Patient discussion about creatine

Q. Q. I want to know about urine protein creatine ratio in diagnosing nephrotic syndrome. Please explain interms of unit such as mg/mg or mmol/mg. Normal range, nephrotic range with good referrence.

A. Nephrotic syndrome is defines as a damage to the kidneys, in which there is a leak of large amounts of protein (over 3.5 grams of protein / 24 hours urine output) from the blood to the urine. Protein loss causes low protein count in the blood (hypoalbuminemia) and edemas (excess fluid in the interstitial cavity which is between the cells, causes leg swelling most often, and also in the adbomen and around the eyes).

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References in periodicals archive ?
Ju et al [26] reported that supplementation of creatine in rat diets increased phosphorylation of AMPK protein and increased mRNA expression of GLUT4 in pectoral muscle.
The subjects were divided into three groups in a randomized, double-blind fashion as follows: group G3 (3 g/day creatine supplementation), group G5 (5 g/day creatine supplementation); and group GP (supplementation with placebo, a compound of inert substance with color, solubility, and taste similar to those of creatine, using a dose of 5 g/day).
Some authors do not recommend creatine consumption for children and adolescent (Metzl et al., 2001; Unnithan et al., 2001), in contrast, no international organization prohibits the use, since there is no evidence that the use of creatine would be harmful to young athletes' physical or mental health (Kreider et al., 2017).
1H magnetic resonance spectroscopy: a diagnostic instrument for cerebral creatine deficiency syndrome.
In relation to the Pre group, the Caf group reached an increase of 4.57% in the EMG activity during the whole work, the CrCaf group reached an increase of 3.07%, and the group supplemented with 3 g of Creatine (Cr) had a significant decrease of 17.07% in the EMG activity.
Structure of creatine amidinohydrolase from Actinobacillus.
Concentration of creatine increased from 4032.68 ppm (day 0) to 5650.85 ppm (day 4) and started to decrease at 5174.79 ppm (day 5) until 4631.28 ppm (day 7) before it remained unchanged until day 7 (3.31 x [10.sup.3] ppm) (Figure 6).
Creatine use has also been associated with an increased risk of compartment syndrome, a condition where pressure builds in a muscle compartment and prevents blood flow.
Creatine supplementation with specific view to exercise/sports performance: an update.
The present study was designed to determine the influence of two different doses (1% and 3%) of creatine monohydrate on serum levels of proinflammatory cytokines (IL-6 and IL-18) in female albino mice with neonatal HI insult.
The report also provides information about the uses, dosage, and potential side effects of creatine and BCAAs and explains differences among forms of these ingredients, such as creatine monohydrate, creatine AKG, dicreatine malate, and KreAlkalyn.
As we age, the unique benefits of creatine become more pronounced.