creatine


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Related to creatine: creatinine

creatine

 [kre´ah-tin]
a nonprotein substance synthesized in the body from three amino acids: arginine, glycine (aminoacetic acid), and methionine. Creatine readily combines with phosphate to form phosphocreatine, or creatine phosphate, which is present in muscle, where it serves as the storage form of high-energy phosphate necessary for muscle contraction.
creatine kinase an enzyme catalyzing the transfer of a phosphate group from phosphocreatine to ATP. It has three isoenzymes: CK1, found primarily in the brain; CK2, found in the myocardium; and CK3, found in both skeletal muscle and the myocardium. The presence of CK2 in the blood is strongly indicative of a recent myocardial infarction; it is present until about 72 hours after the attack.

cre·a·tine

(krē'ă-tēn, -tin), Do not confue this word with creatinine.
A compound, N-(aminoiminomethyl)-N-methylglycine, which occurs in urine, sometimes simply as creatine, but generally as creatinine, and in muscle, generally as phosphocreatine. Elevated levels are found in the urine of individuals with muscular dystrophy.

creatine

/cre·a·tine/ (kre´ah-tin) an amino acid occurring in vertebrate tissues, particularly in muscle; phosphorylated creatine is an important storage form of high-energy phosphate.
creatine phosphate  phosphocreatine.

creatine

(krē′ə-tēn′, -tĭn) also

creatin

(-tĭn)
n.
A compound, C4H9N3O2, that is found in the muscle tissue of vertebrates mainly in the form of phosphocreatine and that is involved in storing and supplying energy for muscle contraction.

creatine

[krē′ətēn, -tin]
Etymology: Gk, kreas, flesh
an important nitrogenous compound produced by metabolic processes in the body. Combined with phosphorus, it forms a high-energy phosphate. In normal metabolic reactions the phosphorus is transferred to a molecule of adenosine diphosphate to produce a molecule of very high-energy adenosine triphosphate. See also creatinine.

cre·a·tine

(krē'ă-tin)
N-(aminoiminomethyl) - N-methylglycine; occurs in urine, sometimes as such, but generally as creatinine, and in muscle, generally as phosphocreatine; elevated in urine in muscular dystrophy; synthesized in liver and pancreas from amino acids; absorbed in bloodstream, it is deposited in tissue (e.g., muscles, brain).

creatine

A nitrogenous substance present in all muscle cells.

creatine

a white nitrogenous substance found in vertebrate muscles.

creatine (krēˑ··tīn),

n an amino acid that is created in the body in the kidneys, liver, and pancreas. Used as a supplement by athletes to aid in performance. Not for use by pregnant or nursing women, children, or patients with kidney or heart disease.

creatine

a nonprotein nitrogen substance synthesized in the body from three amino acids: arginine, glycine (aminoacetic acid) and methionine. Creatine readily combines with phosphate to form phosphocreatine, or creatine phosphate, which is present in muscle, where it serves as the storage form of high-energy phosphate necessary for intense muscle contraction.

creatine kinase (CK)
an organ-specific enzyme catalyzing the transfer of a phosphate group from phosphocreatine to ATP. It has three isoenzymes: CK1, found primarily in the brain; CK2, found in the myocardium; and CK3, found in both skeletal muscle and the myocardium. In humans, the presence of CK2 in the blood is useful in diagnosing a recent myocardial infarction, but in animals CK3 is most commonly increased related to muscle damage. Called also creatine phosphokinase, Lohmann's enzyme.
creatine phosphate
see creatine (above).
creatine phosphokinase
called also CPK; see creatine kinase (above).

Patient discussion about creatine

Q. Q. I want to know about urine protein creatine ratio in diagnosing nephrotic syndrome. Please explain interms of unit such as mg/mg or mmol/mg. Normal range, nephrotic range with good referrence.

A. Nephrotic syndrome is defines as a damage to the kidneys, in which there is a leak of large amounts of protein (over 3.5 grams of protein / 24 hours urine output) from the blood to the urine. Protein loss causes low protein count in the blood (hypoalbuminemia) and edemas (excess fluid in the interstitial cavity which is between the cells, causes leg swelling most often, and also in the adbomen and around the eyes).

More discussions about creatine
References in periodicals archive ?
Creatine in red cells: transport and erythropoietic dynamics.
Although several previous studies investigated the effect of WBV training or creatine supplementation sepaately on physical fitness and performance in the elderly, some have reported desirable results.
Often high school creatine users either do not know how much creatine they are taking or are intentionally taking more than the dose recommended on packaging provided by manufacturers.
Creatine kinase-MB elevation after stroke is not cardiac in origin: comparison with troponin T levels.
We have recently reported the effect of creatine monohydrate supplementation on complete blood count and on selected parameters of serum biochemical profile in albino mice following hypoxic ischemic insult and we had observed that creatine supplementation following hypoxic ischemic insult helps in maintaining the normal blood chemistry when compared with the creatine untreated mice indicating that creatine reaches the target sites in intact form when transported via blood following dietary supplementation for variable durations (Iqbal et al.
Ultimately, supplementing with creatine helps restore the energy loss that is at the root of many age-related diseases.
Also, the amounts of several phospholipids in myelin were increased by creatine treatment, particularly in the brain stem, suggesting that improved myelination may contribute to the ability of the piglet to avoid the sow when necessary.
To demonstrate CEST's ability to detect heart disease, the researchers applied the creatine CEST method in an MRI scanner, in healthy and infarcted myocardium (muscle tissue in heart) in large animals.
Findings have also demonstrated that use of creatine and ginseng supplements could enhance ability and power of the middle-aged and elderly [7].
Clearly, the use of creatine results in positive athletic performances.
Groups consisted of a creatine supplementation group (CrS), a placebo supplement group (P), and control (no supplement) (C) group.