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Cranial nerve I is the sensory nerve that conveys odor information from the nose to the brain.
1) It is a very important sign as the tumor is already in stage IV once the cranial nerve is involved.
The first cranial nerve is the purveyor of our chemosenses, smell and taste.
The eighth cranial nerve is commonly affected as it has a long segment exposed to CSF (4) and is particularly well lined by myelin that is supported by haemosiderin-sensitive microglial cells.
The seventh (peripheral facial paresis) or fifth (decreased corneal reflex, facial numbness) cranial nerve is usually involved.