coumarin


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coumarin

 [koo´mah-rin]
1. a principle extracted from the tonka bean, from which several anticoagulants are derived that inhibit hepatic synthesis of vitamin K–dependent coagulation factors.
2. any of these derivatives.

cou·ma·rin

(kū'mă-rin),
1. A general descriptive term applied to anticoagulants and other drugs derived from dicumarol, a component of the Tonka bean.
2. A fragrant neutral principle obtained from the Tonka bean, Dypterix odorata, and made synthetically from salicylic aldehyde; it is used to disguise unpleasant odors.
[coumarou, native name of Tonka bean]

coumarin

(ko͞o′mər-ĭn)
n.
A fragrant crystalline compound, C9H6O2, present in tonka beans and produced synthetically for use as a fragrance. Coumarin has been banned as a food additive in the United States because it can be toxic in large amounts.

cou′ma·ric (-mər-ĭk) adj.

cou·ma·rin

(kū'mă-rin)
Fragrant neutral principle obtained from the Tonka bean, Dypterix odorata, and also made synthetically from salicylic aldehyde; used to disguise unpleasant odors.

cou·ma·rin

(kū'mă-rin)
A general descriptive term applied to anticoagulants and other drugs derived from dicumarol.
References in periodicals archive ?
Synthesis of Macromonomer and Comb Copolymer Synthesis of 7-Hydroxy-4-Chloromethyl Coumarin [CMHC]
The mechanism underlying this observation may be MK-7's much longer half-life time in the circulation and its reported 6-fold higher cofactor activity in vitro." However, before continuing, as will be reported shortly, the adverse impact of MK-7 on efficacy of coumarin anticoagulants is dose-dependent.
A) 7-Hydroxy-4', 6-dimethoxyisoflavone; B) chalepin; C) coumarin 2; D) coumarin 3; E) coumarin 4; F) guajaverin; G) coumarin 5; H) isosakuranetin; I) mangiferin; J)3', 4', 5', 5, 7-pentamethoxyflavone; K) quercetin; L) tiliroside.
Investigation of polyphenolic profile of ethanol extracts of Lentinus squarrosulus and Termitomyces robustus showed the presence of phenolic acids, flavonoids and coumarin (Table 1) which have been proofed through researches to possess various antioxidant properties.
The lifetime fluorescence measurements of the coumarin derivative and human serum albumin complex were detected using Fluorolog (Horiba Jobin Yvon IBH, UK) with a fast response sensitive PMT detector (Hamamatsu Photonics, Japan) for an excitation wavelength of 280 nm to 450 nm.
The coumarin derivative (compound 2) was selected here because of its high emission efficiency, facile preparation procedure, excellent water solubility, and biocompatibility.
Figures 4(a) and 4(c) show the wide-field epi-fluorescence image corresponding to two capillary tubes filled with Coumarin 153 solution, stacked perpendicularly to simulate a two-layer tissue, and the corresponding intensity profile for the line drawn on the image.
Coumarin compounds as potential anticancer agents have become a rapidly developing, extremely active, and attractive topic.
reported the synthesis of a series of compounds (32a-e) containing both coumarin and triazolothymidine (AZT-31, a well-known HIV-1 RT inhibitor) moieties to obtain dual action HIV-1 PR and RT inhibitions (Figure 11) [36].
In conclusion, among the coumarin compounds that we successfully synthesized, compounds I c, I d, II c and II d had a strong electron-withdrawing group (-CH2Cl, -Cl, -CN and -CF3) in the phenyl ring with the highest cytotoxic activity against the cancer cell lines tested.