coumarin


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coumarin

 [koo´mah-rin]
1. a principle extracted from the tonka bean, from which several anticoagulants are derived that inhibit hepatic synthesis of vitamin K–dependent coagulation factors.
2. any of these derivatives.

cou·ma·rin

(kū'mă-rin),
1. A general descriptive term applied to anticoagulants and other drugs derived from dicumarol, a component of the Tonka bean.
2. A fragrant neutral principle obtained from the Tonka bean, Dypterix odorata, and made synthetically from salicylic aldehyde; it is used to disguise unpleasant odors.
[coumarou, native name of Tonka bean]

coumarin

/cou·ma·rin/ (koo´mah-rin)
1. a principle extracted from the tonka bean; it contains a factor, dicumarol, that inhibits hepatic synthesis of vitamin K–dependent coagulation factors, and a number of its derivatives are used as anticoagulants in treating disorders characterized by excessive clotting.
2. any of these derivatives or any synthetic compound with similar activity.

coumarin

(ko͞o′mər-ĭn)
n.
A fragrant crystalline compound, C9H6O2, present in tonka beans and produced synthetically for use as a fragrance. Coumarin has been banned as a food additive in the United States because it can be toxic in large amounts.

cou′ma·ric (-mər-ĭk) adj.

coumarin

[ko̅o̅′mərin]
a class of orally active anticoagulant agents with warfarin as its prototype.
indications It is prescribed for prophylaxis and treatment of thrombosis and embolism.
contraindications Known hypersensitivity to the drug prohibits its use. It is not prescribed to patients who are at risk for hemorrhage or who are pregnant.
adverse effects The most serious adverse reaction is hemorrhage. Many other drugs interact with this drug to increase or decrease its effect.

cou·ma·rin

(kū'mă-rin)
Fragrant neutral principle obtained from the Tonka bean, Dypterix odorata, and also made synthetically from salicylic aldehyde; used to disguise unpleasant odors.

coumarin,

n C9H6O, derived from a variety of sources, including tonka bean and sweet clover; may also be artificially manufactured.
Enlarge picture
Coumarin.

cou·ma·rin

(kū'mă-rin)
A general descriptive term applied to anticoagulants and other drugs derived from dicumarol.

coumarin

1. a principle extracted from the tonka bean, from which several anticoagulants are derived, that inhibits hepatic synthesis of vitamin K-dependent coagulation factors.
2. any of these derivatives.
3. see also dicoumarol.
References in periodicals archive ?
The metal complexes and organic coumarin derivatives of H2L were examined for antimicrobial properties.
In conclusion, among the coumarin compounds that we successfully synthesized, compounds I c, I d, II c and II d had a strong electron-withdrawing group (-CH2Cl, -Cl, -CN and -CF3) in the phenyl ring with the highest cytotoxic activity against the cancer cell lines tested.
Bioassay-guided isolation of sesquiterpene coumarins from Ferula narthex Bioss: a new anticancer agent.
Therefore, natural antioxidants such as phenolic, flavonoids, tannins, xanthons, coumarins, curcumanoids and terpenoids should be used (Jeong et al.
Coumarin were found in basil only whereas quinones were present in basil and rosemary.
Method: A sensitive and specific liquid chromatographic-tandem mass (LC-MS/MS) spectrometric method was established to investigate pharmacokinetics of sixteen coumarins of Angelicae dahuricae Radix (ADR) in rat plasma, including xanthotoxol (1), oxypeucedanin hydrate (2), 5-hydroxy-8-methoxypsoralen (3), (-)-marmesin (4), byakangelicin (5), columbianetin (6), psoralen (7), xanthotoxin (8), neobyakangelicol (9), isoimpinellin (10), bergapten (11), heraclenin (12), oxypeucedanin ethanolate (13), imperatorin (14), phellopterin (15), isoimperatorin (16).
Phytochemical analysis of column fractions of Solanum incanum Phytochemical Inference of Column Fractions of Solanum test incanum 1-20(A) 21-35(B) 39-49(C) 50-69(D) Carbohydrates - - + - Tannins test - + + - Saponin test + - - - Alkaloid test + + - + Quinones - - - - Glycosides test - - - - Cardiac glycosides test - - - - Flavonoids - + - Terpenoids test - + - - Triterpenoids - - - - Phenols - - - - Coumarins - + + - Phytochemical Inference of Column Fractions of test Solanum incanum 70-94(E) 95-120(F) 121-135(G) Carbohydrates - + + Tannins test + - - Saponin test - - - Alkaloid test + - - Quinones - - - Glycosides test - - - Cardiac glycosides test - + - Flavonoids + - - Terpenoids test + - - Triterpenoids - - - Phenols - + - Coumarins + - - Table 3.
This study was conducted to identify and quantify the presence of various coumarin derivatives in tarragon leaves and to evaluate the effects of different extracts on anticoagulant activity by the determination of prothrombin time (PT).
8; =CH)], conform the typical [alfa], [beta]-unsaturated [delta]-lactone of a coumarin [alfa]-pyron ring.
Then, epoxypropoxy coumarin (EPC) was conjugated to hydrophobically modified poly (vinyl alcohol)--epoxypropoxy coumarin conjugate (HmPVA) by the reaction between the epoxy groups of EPC and the hydroxyl group of HmPVA (Fig.
Skin necrosis following a prolonged administration of coumarin in a patient with inherited protein C deficiency.
Ceylon cinnamon contains very little coumarin, a naturally occurring substance that has been linked to liver damage in people sensitive to the substance.