A popular animal model first used in polio research, which is a model of choice for research in measles—paramyxovirus—herpes simplex, influenza—orthomyxovirus—HIV-1, respiratory syncytial virus, and adenovirus-based gene replacement research
For example, during the 1900s, several authors (Grinnell, 1914, 1933; Dixon, 1922; Clark, 1972) reported that cotton rats used irrigation canals to invade and establish extensive populations in agricultural fields throughout portions of the Imperial Valley, California.
In previous studies, Viprovex demonstrated the ability to reduce the impact of influenza virus administration in cotton rats, which have included pulmonary inflammation and, in some studies, elevated mortality, which was highest in Tamiflu-treated, influenza-infected animals.
They usually are found in association with cotton rats (Sigmodon) and harvest mice (Reithrodontomys), and prefer grassy areas such as old fields, pastures and along railroads or highways (Schmidly 1983).
Immune markers of infection remain to be assessed, but this pilot study apparently reveals that the ability of Homspera to attenuate symptoms of influenza virus infection, which have previously been reported in cotton rats infected with H3N2 influenza and in ferrets infected with H5N1 influenza, also extends to the current pandemic H1N1 strain.