membrane insertion of the serine proteinase precursor NS2B-NS3(Pro) of dengue virus type 2 is required for efficient in vitro processing and is mediated through the hydrophobic regions of NS2B.
2014) Principles of ER cotranslational
translocation revealed by proximity-specific ribosome profiling.
UCHL1 is also involved in the cotranslational
processing of proubiquitin and ribosomal proteins translated as ubiquitin fusions .
Isolation and characterization of the methionine aminopeptidase from porcine liver responsible for the cotranslational
processing of proteins.
Nine mechanisms of miRNA action are discerned using a unified mathematical model: a) cap-40S initiation inhibition, b) 60S ribosomal unit joining inhibition, c) elongation inhibition, d) ribosome drop-off (premature termination), e) cotranslational
nascent protein degradation, f) sequestration in P-bodies, g) mRNA decay (destabilization), h) mRNA cleavage, and i) transcriptional inhibition through miRNA-mediated chromatin reorganization followed by gene silencing (Figure 4).
function of ribosome-associated Hsp70 in eukaryotic protein homeostasis.
protein folding FKBP8 6/10 Apoptotic process, Mitochondrion [down intracellular membrane arrow] signal transduction, protein folding ALDH2 4/11 Carbohydrate Mitochondrion [down metabolic process, matrix arrow] xenobiotic metabolic process AL3A2 7/27 Cellular aldehyde Endoplasmic [down metabolic process, reticulum arrow] lipid metabolic process K2C8 15/26 Cytoskeleton Cytoplasm, [down organization, nucleus arrow] protein binding ACTBM 11/20 Platelet Cytoplasm, [down activation, ATP cytoskeleton arrow] binding EZRI 10/24 Actin filament Cell membrane [down binding, cell arrow] adhesion IF2A 19/32 Translation Cytoplasm [down initiation arrow] (a.
The use of multiple prediction methods improves prediction of the expression patterns of secretory proteins that undergo signalpeptide-mediated cotranslational
translocation (CTT proteins) in the endoplasmic reticulum and are then transported to the cell surface for membrane incorporation or secretion (1).
All of the clusters have translational overlaps between the vanA and vanX genes and their homologs, suggesting cotranslational
regulation of expression.
A series of cotranslational
and post-translational processing steps prevent ricin from attacking castor's ribosomes.
In this paper, we discuss the role of the basal glutathionylation and provide evidence supporting the view that this modification is cotranslational
2003) N-linked glycans direct the cotranslational
folding pathway of influenza hemagglutinin.