MAP3K8(redirected from cot (cancer Osaka thyroid) oncogene)
MAP3K8An oncogene on chromosome 10p11.23 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K8 is required for TLR4 activation of the MEK/ERK pathway; it activates NF-kappaB 1 by stimulating proteasome-mediated proteolysis of NF-kappaB 1/p105.
Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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