cosyntropin


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cosyntropin

 [ko″sin-tro´pin]
a synthetic corticotropin used in the screening of adrenal insufficiency on the basis of plasma cortisol response after intramuscular or intravenous injection.

co·syn·tro·pin

(kō-sin-trō'pin),
α1-24- or β1-24-Corticotropin; a synthetic corticotrophic agent, comprising the first 24 amino acyl residues of human ACTH, which sequence is found in several other species and which retains the full biologic activity of the complete ACTH; the remaining 15 residues differ among species and confer specific immunologic properties.

cosyntropin

(kō′sĭn-trō′pĭn)
n.
A synthetic corticotropin.
References in periodicals archive ?
These statements involve inherent risks and uncertainties that could cause actual results to differ materially from those projected or anticipated, including risks related to regulatory approval and clinical development of long-acting cosyntropin, expectations regarding royalties to be received based on sales of NUCYNTA and NUCYNTA ER, expectations regarding potential business opportunities and other risks outlined in the Company's public filings with the Securities and Exchange Commission, including the Company's most recent annual report on Form 10-K and subsequent Quarterly Reports on Form 10-Q.
Assertio Therapeutics announced that it has submitted to the FDA a 505 new drug application for its novel injectable formulation of cosyntropin depot with its partner, West Therapeutic Development.
Cosyntropin can be injected to stimulate release of ACTH.
11-Deoxycortisol maybe superior to cortisol in confirming a successful adrenal vein catheterization without cosyntropin: a pilot study.
A screening serum 17-OHP level of > 6 nmol/L was an indication to obtain a complete adrenocortical profile and to perform a highdose (250 [micro]g) cosyntropin stimulation test (HDSST).
Administration of cosyntropin (1-24 ACTH; Cortrosyn) to directly stimulate adrenal cortisol release is the most commonly used diagnostic test to evaluate adrenal function.
Shimshi, "Diagnosing adrenal insufficiency: which test is best-the 1-microg or the 250-microg cosyntropin stimulation test?," Endocrine Practice, vol.
The cosyntropin test can help distinguish between primary and secondary adrenal insufficiency.
under which Depomed will acquire from SlAaAaAeA n rights to market t specialty drug, cosyntropin (Synthetic ACTH Depot) in the United States and divest its Lazanda (fentanyl) nasal spray CII to SlAaAaAeA n, the compa said.
under which Depomed will acquire from SlAaAaAeAaAaAeAeA n rights to market specialty drug, cosyntropin (Synthetic ACTH Depot) in the United States and divest its Lazanda (fentanyl) nasal spray CII to SlAaAaAeAaAaAeAeA n, the com said.
Cosyntropin stimulation testing results show low cortisol, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S) and 17-OH progesterone but high, DOC and corticosterone levels and reveal the adrenal steroidogenic defect (1).