Tasuku Honjo, "for their discovery of cancer therapy by inhibition of negative immune regulation." Among his most notable discoveries are the determination of the T-cell receptor structure and that CD28 is the major costimulatory molecule
that allows full activation of naive T-cells and prevents anergy in T-cell clones.
Freeman, "Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule
to inhibit T cell responses," Immunity, vol.
It plays a vital role in regulating T cell activation and maintaining peripheral tolerance as a core costimulatory molecule
Paolieri et al., "B7.1 costimulatory molecule
is expressed on thyroid follicular cells in Hashimoto's thyroiditis, but not in Graves' disease," The Journal of Clinical Endocrinology & Metabolism, vol.
An example of APC inhibition is the Treg expression of CTLA-4, an inhibitory receptor relative to the T cell costimulatory molecule
More and more researches demonstrated that the cognate interaction between the inducible costimulatory molecule
(ICOS) and ICOS ligand (ICOSL), a member of the CD28 family, is an indispensable signaling for the activation of T cells.
CD8 protein performs the adhesive and costimulatory molecule
function of the T cell receptor and can exist in a soluble form.
Other candidates for the permeability factor are cardiotrophin-like cytokine factor-1 (CLCF-1)  and autoantibodies against the costimulatory molecule
DC maturation is critical for inducing immune responses and can be characterized by cellular morphology and selected costimulatory molecule
expression, such as that of CD86, CD83, CD80, CD40, and MHC I and II.
DCs treated with adenosine 2A receptor ([A.sub.2]AR) agonists protected the kidney from ischemia/reperfusion injury through suppression of IFN-[gamma] production by NK T cells and decreased costimulatory molecule
PVRIG and TIGIT constitute parallel immune checkpoint pathways that counteract DNAM-1, a costimulatory molecule
on T cells and NK cells.