costimulatory molecule

costimulatory molecule

membrane-bound or secreted product of accessory cells that is required for signal transduction.

co·stim·u·la·to·ry mol·e·cule

(kō-stim'yū-lă-tōr'ē mol'ĕ-kyūl)
Membrane-bound or secreted product of accessory cells that is required for signal transduction.
References in periodicals archive ?
sup][5] PD-1, as a negative costimulatory molecule, binds to its ligand programmed death-ligand 1 (PD-L1) to deliver an inhibitory signal that restrains the activation, proliferation, and effector functions of immune cells.
2 (CD86) [23], which is expressed on T cells and is known as the most basic costimulatory molecule.
Other candidates for the permeability factor are cardiotrophin-like cytokine factor-1 (CLCF-1) [4] and autoantibodies against the costimulatory molecule CD40 [5].
DC maturation is critical for inducing immune responses and can be characterized by cellular morphology and selected costimulatory molecule expression, such as that of CD86, CD83, CD80, CD40, and MHC I and II.
After careful consideration, these studies indicate that the choice of costimulatory molecules affects the therapeutic response, but it remains unclear whether any costimulatory molecule is superior to another [40, 41].
mice at baseline and suggested that low levels of alveolar macrophage costimulatory molecule expression are maintained at least in part by endogenous IL-10 activity.
Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: An open-label trial.
In contrast, costimulatory molecule expression appeared not to be different between mature hypoxic or normoxic DCs [28].
As shown in Figure 2, clustering of CR1 by the C3blike ligand dose-dependently inhibited the BCR-induced upregulation of the activation marker, CD69 (Figure 2(a)), and the costimulatory molecule, CD40 (Figure 2(d)), on B cells of healthy individuals.
IDEC-114 is a monoclonal antibody that targets CD80, an immune costimulatory molecule that is routinely expressed at low levels on the surface of follicular lymphomas and other lymphoid malignancies.
CV301 is a poxvirus-based prime/boost vaccine that incorporates a modified version of vaccinia (MVA-BN, a proprietary technology of Bavarian Nordic) as a priming dose, followed by multiple fowlpox boosts, and encodes the TRICOM costimulatory molecules.
Expression of B7-1 costimulatory molecules in patients with multibacillary leprosy and reactional states.