cosmid


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cos·mid

(koz'mid),
A recombinantly engineered plasmid, a circular DNA containing, in order: a plasmid origin of replication and a drug-resistance marker, the cos (cohesive end) site from bacteriophage λ, and a fragment of eukaryotic DNA to be cloned; cosmids are constructed to permit cloning of fragments of up to about 40,000 base pairs in length, with one or more unique restriction sites being necessary to facilitate cloning.
Farlex Partner Medical Dictionary © Farlex 2012

cosmid

(kŏz′mĭd)
n. Genetics
An artificially constructed plasmid used for cloning large genes or other DNA sequences.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

cosmid

a class of CLONING VECTOR which comprises a bacterial PLASMID and the COS SITE of a BACTERIOPHAGE, typically bacteriophage lambda. A cosmid combines features of plasmids and of bacteriophages and can be used in CLONING. Large DNA fragments, up to 40 KILOBASE pairs in size, can be cloned in cosmids. The cosmid can be propagated as a plasmid in vivo and packaged into bacteriophages in vitro.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
A strategy for high-volume sequencing of cosmid DNAs: random and direct priming with a library of oligonucleotides.
Direct carrier detection by in situ suppression hybridization with cosmid clones of the Duchenne/Becker muscular dystrophy locus.
The positions of the CMT1A-REP sequences were confirmed on the BAC clones using sequences of the cosmid clone c74F4 for the proximal CMT1A-REP (17) and c15H12 for the distal CMT1A-REP sequence (31).
The metagenomic expression libraries are created by insertion of fragmented metagenomic DNA into expression vectors based on plasmids, cosmids, fosmids, or phages.
The strategies include subcloning genomic DNA from cosmids to plasmids, mutagenesis of that DNA and placing mutant DNA in the S.
[ClickPress, Wed Oct 10 2018] Fosmids are DNA vectors similar to cosmids with F-factors replication which are used for DNA segregation and replication.