cosegregation

(kō-sĕg-grĕ-gā-shun),

A conceptual term often used to mean "tracking" (for example, an allele cosegregating or "tracking" with a disorder).

References in periodicals archive ?

As expected, cosegregation analysis of the mutations revealed that each parent was a carrier of one alteration.

Diagnosing rate disorders using next generation sequencing

Currently, such supporting evidence includes detecting a recurring de novo mutation in a gene with a deleterious effect on the encoded protein in similarly affected patients, showing cosegregation in family members, and/or providing compelling evidence of the underlying biology and mechanism.

Exome and whole-genome sequencing as clinical tests: a transformative practice in molecular diagnostics

All SGI ROTAV strains were associated with the P[6] or P[4] genotype, and all SGII ROTAV strains were associated with P[8], demonstrating a gene-dependent cosegregation pattern.

Emergence of unusual G6P[6] rotaviruses in Children, Burkina Faso, 2009-2010

Unfortunately, no relatives were available to perform cosegregation analysis.

Identification of four novel LDL receptor gene mutations in the north-west Moroccan population

Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome.

Pathophysiology & genetics of obstructive sleep apnoea

Iodide organification defects resulting from cosegregation of mutated and null thyroid peroxidase alleles.

Genetic factors that might lead to different responses in individuals exposed to perchlorate

Brassicaceae) analysed by a cosegregation of phenotypic characters (QTL) and molecular markers.

AFLP linkage map of an intraspecific cross in Chlamys farreri

The investigators noticed cosegregation of dyslexia, defined by oral reading ability at least two years below expected grade level, and a cytogenetic polymorphism at the top of the acrocentric chromosome 15 in eight families selected on the basis of apparent autosomal dominant transmission of the disorder.

CURRENT UNDERSTANDING OF THE GENETIC BASIS OF READING AND SPELLING DISABILITY

Cosegregation of a novel Bartonella species with Borrelia burgdorferi and Babesia microti in Peromyscus leucopus.

Bartonella spp. transmission by ticks not established

Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia.

Integrated single-label liquid-phase assay of APOE codons 112 and 158 and a lipoprotein study in British women

henselae DNA has been amplified, and that serologic and molecular evidence suggests cosegregation of Bartonella spp.

Potential for tick-borne Bartonelloses

In two families, cosegregation with the disease could not be assessed because of a lack of available DNA samples.

Denaturing HPLC-based approach for detecting RYR2 mutations involved in malignant arrhythmias