cosegregation

(kō-sĕg-grĕ-gā-shun),

A conceptual term often used to mean "tracking" (for example, an allele cosegregating or "tracking" with a disorder).

References in periodicals archive ?

The deletion, concerned with an in-frame deletion of 5 amino acid residues in a highly evolutionarily conserved region within the cytoplasmic loop domain of the gap junction channel protein connexin 50 (Cx50), was in full cosegregation with the cataract phenotypes in the family but not found in 1100 control exomes.

Targeted Genes Sequencing Identified a Novel 15 bp Deletion on GJA8 in a Chinese Family with Autosomal Dominant Congenital Cataracts

These core elements include, but are not limited to (i) locus, disease-specific, commercially and publicly available databases; (ii) peer-reviewed literature that reports clinical, cosegregation, and functional studies; (iii) prediction algorithms; and (iv) information derived from our internal testing experience.

Classifying germline sequence variants in the era of next-generation sequencing

Cosegregation of two unlinked mutant alleles in some cases of autosomal dominant familial exudative vitreoretinopathy.

Familial exudative vitreoretinopathy/Ailevi eksudatif vitreoretinopati

40, 41) When analyzing exome or genome sequences within a family unit, variant prioritization typically takes into account variant cosegregation within the family, based on affected versus unaffected family members.

College of American Pathologists' Laboratory Standards for Next-Generation Sequencing Clinical Tests

For familial cases linkage was confirmed by checking the cosegregation of the marker alleles with the disease phenotype and the haplotypes were constructed for each family demonstrating linkage by identifying the ancestral chromosomes.

Contribution of GLC3A locus to Primary Congenital Glaucoma in Pakistani population

Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells.

Celulas madre y cancer

A cosegregation analysis of zinc (Zn) accumulation and Zn tolerance in the Zn hyperaccumulator Thlaspi caerulescens.

Field germination and survival of experimentally introduced metal hyperaccumulator noccaea caerulescens (Brassicaceae) across a soil metal gradient

Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity.

Strategically aligning a mandala of competencies to advance a transformative vision

Lichter PR, Richards JE, Downs CA, Stringham HM, Boehnke M, Farley FA (1997) Cosegregation of open-angle glaucoma and the nail-patella syndrome.

Bilateral patellar hypoplasia: beyond the skeletal anomalies

As expected, cosegregation analysis of the mutations revealed that each parent was a carrier of one alteration.

Diagnosing rate disorders using next generation sequencing

All SGI ROTAV strains were associated with the P[6] or P[4] genotype, and all SGII ROTAV strains were associated with P[8], demonstrating a gene-dependent cosegregation pattern.

Emergence of unusual G6P[6] rotaviruses in Children, Burkina Faso, 2009-2010

To identify the causative gene locus, cosegregation and homozygosity mapping with markers that are known to be linked with WH/hypotrichosis phenotype was carried out.

Identification of LIPH gene mutation in a consanguineous family segregating the woolly hair/hypotrichosis phenotype