cortisone


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Related to cortisone: cortisol, prednisone

cortisone

 [kor´tĭ-sōn]
a glucocorticoid with significant mineralocorticoid activity, isolated from the adrenal cortex, largely inactive in humans until it is converted to hydrocortisone (cortisol). Cortisone, as the acetate ester, is used as an antiinflammatory and immunosuppressant and for replacement therapy in adrenocortical insufficiency; administered orally or by intramuscular injection.

cortisone

(kōr'ti-sōn), Avoid using this word as a synonym of adrenocortical steroid.
17-hydroxy-11-dehydrocorticosterone, a biologically inactive adrenal corticosteroid produced by the reversible 11-hydroxylation of cortisol (17-hydroxycorticosterone). It was the first glucocorticoid to be used in therapy (1949). Like the endogenous substance, natural and synthetic cortisone administered as a drug exerts no effect until converted to cortisol.

cortisone

(kôr′tĭ-sōn′, -zōn′)
n.
A naturally occurring corticosteroid, C21H28O5, that is converted in the body to cortisol. It is used in synthetic form as a drug, especially to treat adrenal insufficiency, certain allergies, and inflammation, as from rheumatoid arthritis.

cortisone

(1) An older, “short form” for corticosterone. 
(2) Cortisone (17 alpha-,21-dihydroxy-4-pregnene-3,11,20-trione).

cortisone

A glucocorticoid derived from cortisol, the term cortisone may be used generically to refer to all synthetic glucocorticoids

cor·ti·sone

(kōr'ti-sōn)
A glucocorticoid not normally secreted in significant quantities by the human cortex of the suprarenal gland. It exhibits no biologic activity until converted to hydrocortisone (cortisol); it acts on carbohydrate metabolism and influences the nutrition and growth of connective (collagenous) tissues.

cortisone

The first corticosteroid produced for treatment purposes. It is converted to hydrocortisone in the liver. It was used to treat rheumatoid arthritis, severe allergies, adrenal failure and other conditions but has been largely replaced by more powerful synthetic steroids. A brand name is Cortisyl.

cortisone

a GLUCOCORTICOID hormone secreted by the adrenal cortex, whose function is to combat stress. It causes shrinkage of lymph nodes and lowers the white blood cell count, reduces inflammation, promotes healing and stimulates GLUCONEOGENESIS. Cortisone controls its own production, which is triggered by the ADRENOCORTICOTROPIC HORMONE in a negative FEEDBACK MECHANISM.

Cortisone

Glucocorticoid produced by the adrenal cortex in response to stress. Cortisone is a steroid and has anti-inflammatory and immunosuppressive properties.

cor·ti·sone

(kōr'ti-sōn) Avoid using this word as a synonym of adrenocortical steroid.
Biologically inactive adrenal corticosteroid produced by the reversible 11-hydroxylation of cortisol (17-hydroxycorticosterone).
References in periodicals archive ?
"For all conditions, you always want to explore what other medications are available that are safer than prednisone or cortisone," advises Dr.
The third way a dog can get symptoms of an excess of cortisone is if he is given large doses or dosed for a long time with synthetic corticosteroids.
Both samples were analysed for cortisol and cortisone. 0.1 mL of urine or 0.1 mL of saliva was used to assess cortisol and cortisone concentrations, using an isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) method.
Undifferentiated confluent 3T3-L1 cells showed a small amount of the 11[beta]-HSD1 oxoreductase activity (8% of cortisone to cortisol conversion in 2h), while the 11[beta]-HSD1 dehydrogenase activity (i.e., cortisol to cortisone conversion) was negligible in preadipocytes.
Among those who'd received a cortisone shot, 83 percent reported they had completely recovered from tennis elbow by one year.
"You should only get a 20cc shot of cortisone, he gave me a 100cc shot.
Mais pour arreter le medicament a base de cortisone, il faut l'arreter graduellement en diminuant un comprime par jour jusqu'a ce qu'on arrive a une dose d'un comprime par jour qu'on garde pendant un mois au moins.
The LC-MS/MS reference interval is <2.8 nmol/L for LNSC and <28 nmol/L for late-night salivary cortisone. The reference interval for the salivary cortisol-to-cortisone ratio is 0.2-1.1 at awakening (when the cortisol concentration is typically at its circadian peak) and 0.1-1.2 for late-night samples (the circadian nadir).
"He was being treated with cortisone on a permanent basis.
And the Yorkshire golfer, who thought the main event of this week would be having a cortisone injection in his back, said: "It's just nice to be in it.
"I gave it my best but I can do better," admitted Murray (left), who had a cortisone injection in his right elbow to play.