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a glucocorticoid with significant mineralocorticoid activity, isolated from the adrenal cortex, largely inactive in humans until it is converted to hydrocortisone (cortisol). Cortisone, as the acetate ester, is used as an antiinflammatory and immunosuppressant and for replacement therapy in adrenocortical insufficiency; administered orally or by intramuscular injection.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
cortisone(kōr'ti-sōn), Avoid using this word as a synonym of adrenocortical steroid.
17-hydroxy-11-dehydrocorticosterone, a biologically inactive adrenal corticosteroid produced by the reversible 11-hydroxylation of cortisol (17-hydroxycorticosterone). It was the first glucocorticoid to be used in therapy (1949). Like the endogenous substance, natural and synthetic cortisone administered as a drug exerts no effect until converted to cortisol.
Synonym(s): Wintersteiner compound E
Farlex Partner Medical Dictionary © Farlex 2012
A naturally occurring corticosteroid, C21H28O5, that is converted in the body to cortisol. It is used in synthetic form as a drug, especially to treat adrenal insufficiency, certain allergies, and inflammation, as from rheumatoid arthritis.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
cortisone(1) An older, “short form” for corticosterone.
(2) Cortisone (17 alpha-,21-dihydroxy-4-pregnene-3,11,20-trione).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
cortisoneA glucocorticoid derived from cortisol, the term cortisone may be used generically to refer to all synthetic glucocorticoids
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
A glucocorticoid not normally secreted in significant quantities by the human cortex of the suprarenal gland. It exhibits no biologic activity until converted to hydrocortisone (cortisol); it acts on carbohydrate metabolism and influences the nutrition and growth of connective (collagenous) tissues.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
cortisoneThe first corticosteroid produced for treatment purposes. It is converted to hydrocortisone in the liver. It was used to treat rheumatoid arthritis, severe allergies, adrenal failure and other conditions but has been largely replaced by more powerful synthetic steroids. A brand name is Cortisyl.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
cortisonea GLUCOCORTICOID hormone secreted by the adrenal cortex, whose function is to combat stress. It causes shrinkage of lymph nodes and lowers the white blood cell count, reduces inflammation, promotes healing and stimulates GLUCONEOGENESIS. Cortisone controls its own production, which is triggered by the ADRENOCORTICOTROPIC HORMONE in a negative FEEDBACK MECHANISM.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
Glucocorticoid produced by the adrenal cortex in response to stress. Cortisone is a steroid and has anti-inflammatory and immunosuppressive properties.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
cor·ti·sone(kōr'ti-sōn) Avoid using this word as a synonym of adrenocortical steroid.
Biologically inactive adrenal corticosteroid produced by the reversible 11-hydroxylation of cortisol (17-hydroxycorticosterone).
Medical Dictionary for the Dental Professions © Farlex 2012