corticotropin-releasing factor

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cor·ti·co·tro·pin-re·leas·ing hor·mone (CRH),

a factor secreted by the hypothalamus that stimulates the pituitary to release adrenocorticotropic hormone.

cor·ti·co·tro·pin-re·leas·ing hor·mone

(CRH) (kōr'ti-kō-trō'pin-rĕ-lēs'ing hōr'mōn)
A factor secreted by the hypothalamus that stimulates the pituitary to release adrenocorticotropic hormone.
Synonym(s): corticoliberin, corticotropin-releasing factor.

corticotropin-releasing factor (korˈ·ti·kō·trōˑ·pin-rē·lēˑ·sing fakˑ·ter),

n substance secreted by the hypo-thalamus that triggers the pituitary-adrenal axis. The increased release of this substance plays a significant role in immunosuppression and has other secondary effects. Also called
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Corticotropin-releasing factor.

cor·ti·co·tro·pin-re·leas·ing hor·mone

(CRH) (kōr'ti-kō-trō'pin-rĕ-lēs'ing hōr'mōn)
Factor secreted by hypothalamus that stimulates pituitary to release adrenocorticotropic hormone.
Synonym(s): corticotropin-releasing factor.


1. adrenocorticotropic hormone. See also acth.
2. a pharmaceutical preparation derived from the anterior pituitary of mammals and used to stimulate adrenal cortical activity in various conditions, such as allergy, hypersensitivity and rheumatoid arthritis. It has also been used experimentally in a large number of disorders.

corticotropin-like intermediary peptide
a polypeptide hormone of the intermediate pituitary; stimulates insulin release from the pancreas.
corticotropin-releasing factor
secreted by the hypothalamus and conveyed by local circulation to the corticotrophs in the pituitary which are then stimulated to produce ACTH. Called also corticotropin-releasing hormone (CRF).
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The amygdala: Corticotropin-releasing factor, steroids, and stress.
In all these cases, increased activity of a signaling molecule called corticotropin-releasing factor (CRF) was found to be a critical mediating factor.
Characterization of the relaxant action of urocortin, a new peptide related to corticotropin-releasing factor in the rat isolated basilar artery.
Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: An immunohistochemical study.
The signaling molecule corticotropin-releasing factor (CRF), a 41-amino acid neuropeptide (1) with wide distribution throughout the brain and high concentrations in cell bodies in part of the hypothalamus (i.
They are more sensitive to a key stress hormone with even small amounts sending their emotions into a whirl, while men are relatively immune to even high amounts of the chemical, which is called corticotropin-releasing factor (CRF).
NTI") today announced the enrollment of the first patient into the second of two Phase III pivotal trials of XERECEPT(R), Corticotropin-Releasing Factor, for the indication of peritumoral brain edema.
But the cells did secrete ACTH when they repeated the experiments using corticotropin-releasing factor (CRF) instead of IL-1.
Normal brain functions rely on appropriate levels of the neurotransmitter corticotropin-releasing factor (CRF).
It is an important component of the hypothalamic-pituitary-adrenal (HPA) axis and often is produced in response to biological stress (along with corticotropin-releasing factor from the hypothalamus).

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