corticotropin-releasing factor

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cor·ti·co·tro·pin-re·leas·ing hor·mone (CRH),

a factor secreted by the hypothalamus that stimulates the pituitary to release adrenocorticotropic hormone.

cor·ti·co·tro·pin-re·leas·ing hor·mone

(CRH) (kōr'ti-kō-trō'pin-rĕ-lēs'ing hōr'mōn)
A factor secreted by the hypothalamus that stimulates the pituitary to release adrenocorticotropic hormone.
Synonym(s): corticoliberin, corticotropin-releasing factor.

corticotropin-releasing factor (korˈ·ti·kō·trōˑ·pin-rē·lēˑ·sing fakˑ·ter),

n substance secreted by the hypo-thalamus that triggers the pituitary-adrenal axis. The increased release of this substance plays a significant role in immunosuppression and has other secondary effects. Also called
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Corticotropin-releasing factor.

cor·ti·co·tro·pin-re·leas·ing hor·mone

(CRH) (kōr'ti-kō-trō'pin-rĕ-lēs'ing hōr'mōn)
Factor secreted by hypothalamus that stimulates pituitary to release adrenocorticotropic hormone.
Synonym(s): corticotropin-releasing factor.


1. adrenocorticotropic hormone. See also acth.
2. a pharmaceutical preparation derived from the anterior pituitary of mammals and used to stimulate adrenal cortical activity in various conditions, such as allergy, hypersensitivity and rheumatoid arthritis. It has also been used experimentally in a large number of disorders.

corticotropin-like intermediary peptide
a polypeptide hormone of the intermediate pituitary; stimulates insulin release from the pancreas.
corticotropin-releasing factor
secreted by the hypothalamus and conveyed by local circulation to the corticotrophs in the pituitary which are then stimulated to produce ACTH. Called also corticotropin-releasing hormone (CRF).
References in periodicals archive ?
Increased ethanol self-administration and anxiety-like behavior during acute withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor.
These results demonstrate that CRF-induced inhibition of gastric emptying can be antagonized by the EO, that is, the EO improves restraint stress-induced inhibition of gastric emptying mainly via central corticotropin-releasing factor in rats.
Phylogeny of the corticotropin-releasing factor family of peptides in the metazoa.
The role of corticotropin-releasing factor in stress-induced relapse to alcohol seeking', Psychopharm.
Effects of corticotropin-releasing factor (CRF) and opiates on amphibian locomotion.
Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation.
Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder.
Hypothalamic control of adrenocorticotropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor.
Catecholaminergic modulation of corticotropin-releasing factor and adrenocorticotropin secretion.
3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8(1-ethylpropyl)- 2,6-dimethyl-imidazo [1,2-b] pyridazine: A novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.
Researchers are focusing on the hypothalamus because it releases more corticotropin-releasing factor when threatened, causing the HPA axis to rev up quickly under stress as part of the "fight or flight response," he explained.
A deficit in brain levels of corticotropin-releasing factor immunoreactivity is clearly present in early dementia and may prove to be a neurochemical marker for Alzhei mer's disease, reported Dr.

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