corticotropin


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Related to corticotropin: corticotropin releasing factor

corticotropin

 [kor″tĭ-ko-tro´pin]
1. a hormone secreted by the anterior lobe of the pituitary gland that stimulates the cortex of the adrenal gland to secrete its hormones, including corticosterone. If production of corticotropin falls below normal, the adrenal cortex decreases in size, and production of the cortical hormones declines.
2. a pharmaceutical preparation of animal-derived corticotropin, administered intravenously for diagnostic testing of adrenocortical function and subcutaneously or intramuscularly, in a slowly absorbed gel form (repository corticotropin), as an anticonvulsant for treating infantile spasms. Called also adrenocorticotropic hormone (ACTH), adrenocorticotropin, and corticotrophin.

a·dre·no·cor·ti·co·tro·pic hor·mone (ACTH),

the hormone of the anterior lobe of the hypophysis that governs the nutrition and growth of the adrenal cortex, stimulates it to functional activity, and shows extraadrenal adipokinetic activity; it is a polypeptide containing 39 amino acids, but exact structure varies from one species to another; sometimes prefixed by α to distinguish it from β-corticotropin. The first 13 amino acids at the N-terminal region are identical to α-melanotropin.

corticotropin

(kôr′tĭ-kō-trō′pən) also

corticotrophin

(-trō′fĭn)
n.
See ACTH.

corticotropin

 ACTH, see there.

ad·re·no·cor·ti·co·tro·pic hor·mone

(ACTH) (ă-drē'nō-kōr'ti-kō-trō'pik hōr'mōn)
The hormone of the anterior lobe of the hypophysis that governs the nutrition and growth of the cortex of the suprarenal gland and stimulates it to functional activity; also possesses extraadrenal adipokinetic activity.
Synonym(s): adrenotropin, corticotropin.

adrenocorticotropic, adrenocorticotrophic hormone (ACTH) or corticotropin

a small, proteinaceous hormone secreted by the anterior lobe of the PITUITARY. It controls the secretion of other hormones of the cortex of the ADRENAL GLAND.
References in periodicals archive ?
Ferguson, "Differential regulation of corticotropin releasing factor 1a receptor endocytosis and trafficking by [beta]-arrestins and Rab GTPases," Journal of Neurochemistry, vol.
Urocortins and corticotropin releasing factor type 2 receptors in the hypothalamus and the cardiovascular system.
Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications.
This view is supported by Selye and Stone's (8) experimental transformation of adrenal into myeloid tissue by using extracts of corticotropin and testosterone.
Blunted adrenocorticotropin hormone and [Beta]-endorphin responses after corticotropin releasing factor administration
The Role of the Hypothalamus and Pituitary Gland GHRH: growth hormone releasing hormone PRH: prolactin releasing hormone CRH: corticotropin releasing hormone TRH: thyroid releasing hormone GRH: gonadotropin releasing hormone GH: growth hormone PL: prolactin CH: corticotrophin TSH: thyroid stimulating hormone FSH: follicle stimulating hormone LH: luteinizing hormone The pituitary is located at the base of the brain.
Since the adrenal axis had been shown to be responsive to HTH in an age-dependent manner |11~, it was of interest to assess the corticotropin (ACTH)-releasing activity of histones and other related peptides on pituitary cells from young and mature animals.
Mallinckrodt plc a leading global specialty biopharmaceutical company, confirmed it has achieved 50 percent patient enrollment in the company's Phase 2B study designed to assess the efficacy and safety of Acthar Gel (repository corticotropin injection) as an investigational treatment for amyotrophic lateral sclerosis (ALS).
M2 EQUITYBITES-January 18, 2017-ANI names Karen Quinn PhD as VP, Corticotropin Regulatory Affairs
Acthar Gel (repository corticotropin injection) is an injectable drug approved by the US FDA for the treatment of 19 indications.
(NASDAQ: ANIP) has closed the acquisition of the NDAs for purified corticotropin gel and corticotropin-zinc hydroxide from US-based drugmaker Merck for USD 75m in cash and a percentage of future net sales, the company said.
Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence.

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