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1. a hormone secreted by the anterior lobe of the pituitary gland that stimulates the cortex of the adrenal gland to secrete its hormones, including corticosterone. If production of corticotropin falls below normal, the adrenal cortex decreases in size, and production of the cortical hormones declines.
2. a pharmaceutical preparation of animal-derived corticotropin, administered intravenously for diagnostic testing of adrenocortical function and subcutaneously or intramuscularly, in a slowly absorbed gel form (repository corticotropin), as an anticonvulsant for treating infantile spasms. Called also adrenocorticotropic hormone (ACTH), adrenocorticotropin, and corticotrophin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Corticotropin, adrenocorticotrophic hormone (ACTH), a hormone produced by the PITUITARY GLAND which stimulates the adrenal cortex to secrete steroids in response to stress.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005


Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Adrenocorticotropin (corticotrophin)

A hormone that acts on cells of the adrenal cortex, causing them to produce male sex hormones and hormones that control water and mineral balance in the body.
Mentioned in: Pituitary Dwarfism
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Hypothalamic cocaine- and amphetamine-regulated transcript and corticotrophin releasing factor neurons are stimulated by extracellular volume and osmotic changes.
Morphine dependence increased HPA axis activity with changes in corticotrophin releasing hormone (CRH) mRNA gene expression in selective neurons of the paraventricular nucleus.
The patients with suppressed post DST cortisol levels were considered to have non-functional adenoma, if they additionally had at least one of the following criteria: (i) morning dehydroepiandrosterone sulfate (DHEA-S) levels[greater than or equal to]40 [micro]g/dl, (ii) non-suppressed plasma corticotrophin (normal value: [greater than or equal to]5 pg/ml) or (iii) UFC<110 [micro]g/day.
Changes in the peripheral blood leucocyte populations following an injection of corticotrophin in the immature chicken.
The evaluation of the eosinopenic response to corticotrophin and cortisone in the newborn infant.
Treatment of acute exacerbations with corticotrophin (ACTH).
Novel agents as CRF (Corticotrophin Releasing Factor) antagonists can reduce the high levels ofCRF in blood in anxiety disorders, depression, anorexia nervosa and posttraumatic or post-ischemic neuropsychiatric disorders.
(37) Other neuroendocrine substances and structures involved include, but not limited to, serotonin, norepinephrine, N-methyl-D-aspartate receptors, opioid peptide receptors, [gamma]-Aminobutyric acid (GABA) systems, dynorphin, acetylcholine, corticotrophin releasing factor, adrenocorticotropic hormone, and corticosterone.
MRI--magnetic resonance imaging, ACTH--adrenal corticotrophin thyroid hormone, CT scan--computadorizred tomography.
Weinstock (2008) explored the effect of stress-induced levels of cortisol and corticotrophin releasing hormone in pregnancy.
They were found to have higher levels of corticotrophin and cortisol than did normal controls, indicating that they have an overactive hypothalamic-pituitary adrenal (HPA) axis (20).
In atypical depression we find hyperphagia, nervousness, hypersomnia and fatigue that are related with the low secretion of CRH (Corticotrophin Releasing Hormone).

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