1,8) Three main pathways appear relevant: a prolactin-GH-thyroidstimulating hormone (TSH) pathway regulated by transcription factor Pit-1, (9-11) a gonadotroph pathway regulated by steroidogenic factor 1 (SF-1), (12,13) and a corticotroph
pathway mediated by T-box transcription factor (Tpit).
Background: Two recent whole-exome sequencing researches identifying somatic mutations in the ubiquitin-specific protease 8 (USP8) gene in pituitary corticotroph
adenomas provide exciting advances in this field.
axis sensitivity after exercise in endurance-trained athletes.
adenomas (~10% of pituitary tumors) stain immunopositive for ACTH.
In our patient, inappropriate secretion of ACTH from a corticotroph
adenoma or hyperplasia in a brief period may be described by inappropriate replacement with synthetic glucocorticoid.
Histological and immunohistochemical findings led to identification of corticotroph
adenocarcinoma in the pituitary gland.
Proliferation of lactosomatotroph GH3 and somatotroph MtT/S rat pituitary cells as well as of corticotroph
AtT20 mouse pituitary cells was inhibited by curcumin in monolayer cell culture and in colony formation assay in soft agar.
Treatment is withdrawal of exogenous steroids (if possible) for iatrogenic Cushing's syndrome, or surgical removal of the ACTH-producing pituitary corticotroph
adenoma (classically) in cases of endogenous Cushing's disease.
Impaired procession of proopiomelanocortin in corticotroph
But you failed to include an often overlooked reason for secondary osteoporosis, Cushing's disease, which results in endogenous hypercortisolism due to excessive production of adrenocorticotropic hormone (ACTH) from either an adenohypophyseal corticotroph
adenoma or corticotrophic hyperplasia.
It also acts on other central and peripheral receptors and exhibits other actions, including stimulation of lactotroph and corticotroph
secretion; it also influences gastroenteropancreatic functions and has orexigenic, metabolic, cardiovascular, and antiproliferative effects (60-62).
In contrast, in most pituitary adenomas, either a single hormonal type (as in most pure prolactinomas and corticotroph
adenomas) is present, or common combinations of hormones (FSH-LH-ASU or GH-PRL with occasional ASU) are found.