corticotroph

corticotroph

 [kor´tĭ-ko-trōf]
a type of acidophil found in the anterior lobe of the pituitary gland that secretes corticotropin; it is synthesized as a large prohormone containing both corticotropin and β-lipotropin.

cor·ti·co·troph

(kōr'ti-kō-trof),
A cell of the adenohypophysis that produces adrenocorticotropic hormone (ACTH).

corticotroph

/cor·ti·co·troph/ (kor´tĭ-ko-trōf) an acidophil of the adenohypophysis that secretes corticotropin.

corticotroph

[kor′tikōtrof′]
a small, irregularly stellate, acidophilic cell of the adenohypophysis, having small, sparsely distributed secretory granules and secreting adrenocorticotropic hormone and beta-endorphin. Also called corticotrope, corticotropic cell.

cor·ti·co·troph

(kōr'ti-kō-trōf)
A cell of the adenohypophysis that produces adrenocorticotropic hormone.
References in periodicals archive ?
1,8) Three main pathways appear relevant: a prolactin-GH-thyroidstimulating hormone (TSH) pathway regulated by transcription factor Pit-1, (9-11) a gonadotroph pathway regulated by steroidogenic factor 1 (SF-1), (12,13) and a corticotroph pathway mediated by T-box transcription factor (Tpit).
Background: Two recent whole-exome sequencing researches identifying somatic mutations in the ubiquitin-specific protease 8 (USP8) gene in pituitary corticotroph adenomas provide exciting advances in this field.
Corticotroph adenomas (~10% of pituitary tumors) stain immunopositive for ACTH.
In our patient, inappropriate secretion of ACTH from a corticotroph adenoma or hyperplasia in a brief period may be described by inappropriate replacement with synthetic glucocorticoid.
Histological and immunohistochemical findings led to identification of corticotroph adenocarcinoma in the pituitary gland.
Proliferation of lactosomatotroph GH3 and somatotroph MtT/S rat pituitary cells as well as of corticotroph AtT20 mouse pituitary cells was inhibited by curcumin in monolayer cell culture and in colony formation assay in soft agar.
Treatment is withdrawal of exogenous steroids (if possible) for iatrogenic Cushing's syndrome, or surgical removal of the ACTH-producing pituitary corticotroph adenoma (classically) in cases of endogenous Cushing's disease.
Impaired procession of proopiomelanocortin in corticotroph macroadenomas.
But you failed to include an often overlooked reason for secondary osteoporosis, Cushing's disease, which results in endogenous hypercortisolism due to excessive production of adrenocorticotropic hormone (ACTH) from either an adenohypophyseal corticotroph adenoma or corticotrophic hyperplasia.
It also acts on other central and peripheral receptors and exhibits other actions, including stimulation of lactotroph and corticotroph secretion; it also influences gastroenteropancreatic functions and has orexigenic, metabolic, cardiovascular, and antiproliferative effects (60-62).
In contrast, in most pituitary adenomas, either a single hormonal type (as in most pure prolactinomas and corticotroph adenomas) is present, or common combinations of hormones (FSH-LH-ASU or GH-PRL with occasional ASU) are found.